Document Detail

Caffeine as a possible cause of ventricular arrhythmias during the healing phase of acute myocardial infarction.
MedLine Citation:
PMID:  2437789     Owner:  NLM     Status:  MEDLINE    
Caffeine (300 mg) was administered to each of 70 patients a mean (+/- standard error of the mean) of 7 +/- 1 days after the onset of acute myocardial infarction to determine its effects on ventricular arrhythmias. The study was designed as a randomized, double-blind, within-patient comparison between caffeine and placebo. Continuous Holter electrocardiographic recording for 4 hours showed no significant differences in the proportion of patients who had ventricular ectopic activity or the total number and complexity of ventricular premature complexes after caffeine vs placebo. Caffeine increased mean blood pressure from 116 +/- 2/70 +/- 1 mm Hg to a maximum of 125 +/- 3/78 +/- 2 mm Hg (p less than 0.001) at 4 hours. Plasma epinephrine increased (p less than 0.01) from 58 +/- 4 pg/ml to a maximum 88 +/- 6 pg/ml 3 hours after caffeine ingestion, whereas the plasma norepinephrine level did not change. Although caffeine caused significant hemodynamic and humoral responses in this population of relatively caffeine-naive postinfarction patients, it did not increase the occurrence or severity of ventricular arrhythmias.
M G Myers; L Harris; F H Leenen; D M Grant
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  59     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1024-8     Citation Subset:  AIM; IM    
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MeSH Terms
Arrhythmias, Cardiac / chemically induced*
Blood Pressure / drug effects
Caffeine / toxicity*
Cardiac Complexes, Premature / chemically induced
Double-Blind Method
Middle Aged
Monitoring, Physiologic
Myocardial Infarction / complications*
Random Allocation
Tachycardia, Supraventricular / chemically induced
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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