| Caffeic acid phenethyl ester to inhibit posterior capsule opacification in rabbits. | |
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MedLine Citation:
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PMID: 9456418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess whether caffeic acid phenethyl ester (CAPE) prevents posterior capsule opacification (PCO) by suppressing the transformation of the lens epithelial cells. SETTING: Departments of Ophthalmology, Chemistry, and Pathology, Turgut Ozal Medical Center, University of Inonu, Malatya, Turkey. METHODS: Twenty pigmented island rabbits having phacoemulsification in their right eyes were randomized into two groups. In group 1, 10 micrograms/ml of CAPE was added to the anterior chamber irrigating solution and a 1% solution of CAPE was injected subconjunctivally for 3 weeks postoperatively. The irrigating solution in Group 2 (control) did not include CAPE. The development of PCO was assessed weekly and its density was graded by slitlamp biomicroscopy. Histologic analysis was performed 3 months after surgery. RESULTS: Group 1 had clear capsules or minor PCO. Group 2 developed more severe PCO or complete opacification. The difference between the two groups was statistically significant (P = .04). CONCLUSION: These preliminary results indicate that CAPE is effective in suppressing PCO in pigmented rabbits and may be beneficial in clinical use in humans because it has no documented harmful effects on normal cells. |
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Authors:
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I F Hepsen; H Bayramlar; A Gultek; S Ozen; F Tilgen; C Evereklioglu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cataract and refractive surgery Volume: 23 ISSN: 0886-3350 ISO Abbreviation: J Cataract Refract Surg Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-02-23 Completed Date: 1998-02-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8604171 Medline TA: J Cataract Refract Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1572-6 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Turgut Ozal Medical Center, University of Inonu, Malatya, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anterior Chamber / drug effects Antioxidants / pharmacology* Caffeic Acids / pharmacology* Cataract / etiology, pathology, prevention & control* Epithelial Cells / drug effects, pathology Esters Lens Capsule, Crystalline / drug effects*, pathology Phacoemulsification / adverse effects Postoperative Complications / etiology, pathology, prevention & control* Rabbits Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Caffeic Acids; 0/Esters; 331-39-5/caffeic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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