Document Detail


Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma.
MedLine Citation:
PMID:  18299139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Caffeic acid phenethyl ester (CAPE) is a biologically active ingredient of propolis, which has several interesting biological properties, including antioxidant and anti-inflammatory; however, its anti-allergic effects are poorly understood. The objective of this study was to determine whether treatment with CAPE results in significant inhibition of asthmatic reactions in a mouse model. Mice sensitized and challenged with ovalbumin (OVA) had the following typical asthmatic reactions: an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing; the development of airway hyperresponsiveness (AHR); the presence of tumor necrosis factor-alpha (TNF-alpha) and Th2 cytokines, including IL-4 and IL-5, in the BAL fluid; and the presence of allergen-specific IgE in the serum. Five successive intraperitoneal administrations of CAPE before the last airway OVA challenge resulted in significant inhibition of characteristic asthmatic reactions. We determined that increased generation of reactive oxygen species (ROS) by inhalation of OVA was diminished via the administration of CAPE in BAL fluid, as well as nuclear factor-kappaB (NF-kappaB) DNA binding activity. These findings indicate that oxidative stress may have a crucial function in the pathogenesis of bronchial asthma, and that CAPE may be useful as an adjuvant therapy for the treatment of bronchial asthma.
Authors:
Won-Kyo Jung; Da-Young Lee; Yung Hyun Choi; Sung Su Yea; Inhak Choi; Sae-Gwang Park; Su-Kil Seo; Soo-Woong Lee; Chang-Min Lee; Se-kwon Kim; You-Jin Jeon; Il-Whan Choi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-05
Journal Detail:
Title:  Life sciences     Volume:  82     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-14     Completed Date:  2008-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  797-805     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Center for Viral Disease Research, Bio-Marker Research Center for Personalized Therapy, Inje University College of Medicine, Busan 614-735, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  pharmacology,  therapeutic use*
Asthma* / immunology,  pathology,  prevention & control
Blotting, Western
Bronchoalveolar Lavage Fluid / cytology,  immunology
Caffeic Acids / administration & dosage,  pharmacology,  therapeutic use*
Cell Count
Cytokines / immunology
Disease Models, Animal
Eosinophils / drug effects,  immunology,  metabolism
Female
Immunoglobulin E / blood
Lung* / drug effects,  immunology,  pathology
Mice
Mice, Inbred BALB C
NF-kappa B / antagonists & inhibitors
Ovalbumin / immunology
Peroxides / metabolism
Phenylethyl Alcohol / administration & dosage,  analogs & derivatives*,  pharmacology,  therapeutic use
Respiratory Hypersensitivity / immunology,  pathology,  prevention & control
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Caffeic Acids; 0/Cytokines; 0/NF-kappa B; 0/Peroxides; 104594-70-9/caffeic acid phenethyl ester; 37341-29-0/Immunoglobulin E; 60-12-8/Phenylethyl Alcohol; 9006-59-1/Ovalbumin

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