Document Detail


Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells.
MedLine Citation:
PMID:  22347457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Caffeic acid phenethyl ester (CAPE) treatment suppressed proliferation, colony formation, and cell cycle progression in PC-3 human prostate cancer cells. CAPE decreased protein expression of cyclin D1, cyclin E, SKP2, c-Myc, Akt1, Akt2, Akt3, total Akt, mTOR, Bcl-2, Rb, as well as phosphorylation of Rb, ERK1/2, Akt, mTOR, GSK3α, GSK3β, PDK1; but increased protein expression of KLF6 and p21(Cip1). Microarray analysis indicated that pathways involved in cellular movement, cell death, proliferation, and cell cycle were affected by CAPE. Co-treatment of CAPE with chemotherapeutic drugs vinblastine, paclitaxol, and estramustine indicated synergistic suppression effect. CAPE administration may serve as a potential adjuvant therapy for prostate cancer.
Authors:
Hui-Ping Lin; Shih Sheng Jiang; Chih-Pin Chuu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-07
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-07-31     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e31286     Citation Subset:  IM    
Affiliation:
Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / pharmacology
Caffeic Acids / pharmacology*,  therapeutic use
Cell Cycle
Cell Death
Cell Line, Tumor
Cell Movement
Cell Proliferation / drug effects*
Drug Synergism
Humans
Male
Microarray Analysis
Phenylethyl Alcohol / analogs & derivatives*,  pharmacology,  therapeutic use
Phosphorylation
Prostatic Neoplasms / drug therapy*
Proto-Oncogene Proteins c-akt / antagonists & inhibitors*
Signal Transduction / drug effects
p21-Activated Kinases / biosynthesis*
Chemical
Reg. No./Substance:
0/Caffeic Acids; 60-12-8/Phenylethyl Alcohol; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.1/p21-Activated Kinases; G960R9S5SK/caffeic acid phenethyl ester
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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