Document Detail

Caffeic Acid Inhibits Chromium(VI)-Induced Oxidative Stress and Changes in Brush Border Membrane Enzymes in Rat Intestine.
MedLine Citation:
PMID:  22328309     Owner:  NLM     Status:  Publisher    
We have previously shown that a single oral dose of potassium dichromate results in a decrease in the activities of several brush border membrane enzymes, produces oxidative stress, and alters the activities of several antioxidant enzymes in the small intestine of rats. In the present study, we have investigated the effect of treatment with the dietary antioxidant caffeic acid on potassium dichromate-induced biochemical changes in the rat intestine. Adult male Wistar rats were randomly divided into four groups: control, potassium dichromate alone, caffeic acid alone, and potassium dichromate + caffeic acid. Administration of a single oral dose of potassium dichromate alone (100 mg/kg body mass) led to a decrease in the activities of brush border membrane enzymes, increase in lipid peroxidation, decrease in sulfhydryl groups, and changes in the activities of several antioxidant enzymes. Two oral doses of caffeic acid (each of 250 mg/kg body mass) greatly attenuated the potassium dichromate-induced changes in all these parameters, but the administration of caffeic acid alone had no effect. Thus, caffeic acid is an effective agent in reducing the effects of potassium dichromate on the intestine and could prove to be useful in alleviating the toxicity of chromium(VI) compounds.
N A Arivarasu; Shubha Priyamvada; Riaz Mahmood
Related Documents :
1947879 - Hyaluronic acid in flexor tendon sheath fluid after sheath reconstructions in rabbits. ...
2409229 - Interaction of hyaluronectin with hyaluronic acid oligosaccharides.
6272519 - The cytoplasmic mucin in paget cells of extramammary paget's disease.
22464029 - Predicted toxicity of naphthenic acids present in oil sands process-affected waters to ...
22483719 - Control of seed germination by light-induced histone arginine demethylation activity.
22417339 - Pomological features, nutritional quality, polyphenol content analysis, and antioxidant...
2541109 - Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m.
9394759 - How does helicobacter pylori cause mucosal damage? its effect on acid and gastrin physi...
3371139 - Influence of age, intestinal transit time, and dietary composition on fecal bile acid p...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-12
Journal Detail:
Title:  Biological trace element research     Volume:  -     ISSN:  1559-0720     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, U.P., India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The Effects of Glutamate and Citrate on Absorption and Distribution of Aluminum in Rats.
Next Document:  C-Reactive Protein, Waist Circumference, and Family History of Heart Attack are Independent Predicto...