Document Detail

Caesarean section and gastrointestinal symptoms, atopic dermatitis, and sensitisation during the first year of life.
MedLine Citation:
PMID:  15499049     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate the effect of caesarean section on gastrointestinal symptoms, atopic dermatitis, and sensitisation to nutritional allergens in infants. METHODS: A total of 865 healthy full term neonates with parental history of allergy participating in the prospective German Infant Nutritional Intervention Program (GINI) were exclusively breast fed during the first four months of life and had a one year follow up. Data were obtained by follow up visits at age 1, 4, 8, and 12 months, weekly diaries for the first six months, and measurement of total and specific IgE at birth and 12 months. RESULTS: Infants born by caesarean section (147/865, 17%) had a greater risk of diarrhoea (OR(adj) 1.46, 95% CI 1.022 to 2.10) and sensitisation to food allergens, both in adjusted (OR(adj) 2.06, 95% CI 1.123 to 3.80) and stratified analyses (by cord blood IgE). Caesarean delivery was not associated with colicky pain and atopic dermatitis. CONCLUSION: Caesarean delivery might be a risk factor for diarrhoea and sensitisation in infants with family history of allergy. Further research in this area seems warranted as choosing caesarean section becomes increasingly popular.
B Laubereau; B Filipiak-Pittroff; A von Berg; A Grübl; D Reinhardt; H E Wichmann; S Koletzko;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  89     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-22     Completed Date:  2004-11-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  993-7     Citation Subset:  AIM; IM    
GSF-National Research Centre for Environment and Health, Institute of Epidemiology, Neuherberg, Germany.
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MeSH Terms
Allergens / immunology
Breast Feeding
Cesarean Section / adverse effects*
Dermatitis, Atopic / etiology*
Diarrhea / etiology*
Follow-Up Studies
Food Hypersensitivity / etiology*
Hypersensitivity / genetics
Immunoglobulin E / blood
Infant, Newborn
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E

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