Document Detail


A Caenorhabditis elegans tissue model of radiation-induced reproductive cell death.
MedLine Citation:
PMID:  16788064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a tissue model of radiation-induced reproductive cell death in the nematode Caenorhabditis elegans. Reproductive cell death is the primary mode of death in tissue multipotential precursor cells, or "clonogens," the targets of cytotoxic therapy, whose elimination results in normal tissue damage as well as solid-tumor eradication. Through extensive morphologic and genetic analysis, we have confirmed that cell death in this model represents reproductive cell death in isolation from apoptotic cell death, affording the opportunity to define the genetic pathways required for protection from reproductive cell death. We have additionally found that the DNA damage response pathway is necessary for protection from reproductive cell death, supporting the long-held tenet that DNA damage is the cause of reproductive cell death and further validating this model. This genetic tissue model provides a valuable tool for oncology-based research and affords a platform to broaden our insight into responses to cytotoxic therapy in tissues.
Authors:
J B Weidhaas; D M Eisenmann; J M Holub; S V Nallur
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-06-20
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  103     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-28     Completed Date:  2006-08-23     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9946-51     Citation Subset:  IM    
Affiliation:
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. joanne.weidhaas@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / cytology,  growth & development,  radiation effects*
Cell Death / genetics
DNA Damage*
Female
Models, Animal
Necrosis / genetics
Phenotype
Radiation, Ionizing
Reproduction / radiation effects
Stem Cells / pathology,  radiation effects*
Vulva / abnormalities,  pathology,  radiation effects*
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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