Document Detail

Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the response to Pseudomonas aeruginosa infection.
MedLine Citation:
PMID:  23212155     Owner:  NLM     Status:  MEDLINE    
The p38 mitogen-activated protein kinase (MAPK) plays an evolutionarily conserved role in the cellular response to microbial infection and environmental stress. Activation of p38 is mediated through phosphorylation by upstream MAPKK, which in turn is activated by MAPKKK. In the Caenorhabditis elegans, the p38 MAPK (also called PMK-1) signaling pathway has been shown to be required in its resistance to bacterial infection. However, how different upstream MAP2Ks and MAP3Ks specifically contribute to the activation of PMK-1 in response to bacterial infection still is not clearly understood. By using double-stranded RNA-mediated interference (RNAi) and genetic mutants of C. elegans, we demonstrate that C. elegans MOM-4, a mammalian TAK1 homolog, is required for the resistance of C. elegans to a P. aeruginosa infection. We have also found that the MKK-4 of C. elegans is required for P. aeruginosa resistance, but not through the regulation of DLK-1. In summary, our results indicate that different upstream MAPKKKs or MAPKKs regulate the activation of PMK-1 in response to P. Aeruginosa.
Ajing Xu; Guojun Shi; Feng Liu; Baoxue Ge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-05
Journal Detail:
Title:  Protein & cell     Volume:  4     ISSN:  1674-8018     ISO Abbreviation:  Protein Cell     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-11     Completed Date:  2013-10-23     Revised Date:  2014-03-13    
Medline Journal Info:
Nlm Unique ID:  101532368     Medline TA:  Protein Cell     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  53-61     Citation Subset:  IM    
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MeSH Terms
Caenorhabditis elegans / enzymology*,  genetics,  immunology,  microbiology*
Caenorhabditis elegans Proteins / genetics,  metabolism*
Disease Resistance
Enzyme Activation
MAP Kinase Kinase 1 / metabolism
MAP Kinase Signaling System*
Membrane Proteins / deficiency,  genetics,  metabolism*
Pseudomonas Infections / enzymology*
Pseudomonas aeruginosa / physiology*
RNA Interference
p38 Mitogen-Activated Protein Kinases / metabolism*
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Membrane Proteins; 0/mom-4 protein, C elegans; EC Mitogen-Activated Protein Kinases; EC Kinase Kinase 1

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