| Caenorhabditis elegans: a model organism for investigating immunity. | |
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MedLine Citation:
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PMID: 22286994 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The nematode Caenorhabditis elegans has been a powerful experimental organism for almost half a century. Over the past ten years, researchers have begun to exploit the power of C. elegans to investigate the biology of a number of human pathogens. This work has uncovered mechanisms of host immunity and pathogen virulence that are analogous to those involved during pathogenesis in humans or other animal hosts, as well as novel immunity mechanisms which appear unique to the worm. More recently, these investigations have uncovered details of the natural pathogens of C. elegans, including the description of a novel intracellular microsporidian parasite as well as new nodaviruses; the first identification of a viral infection of this nematode. In this review, we consider the application of C. elegans to human infectious disease research, as well as considering the nematode response to these natural pathogens. |
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Authors:
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Elizabeth K Marsh; Robin C May |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-27 |
Journal Detail:
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Title: Applied and environmental microbiology Volume: - ISSN: 1098-5336 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7605801 Medline TA: Appl Environ Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Biosciences, University of Birmingham, Birmingham, West Midlands, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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