Document Detail


The Caenorhabditis elegans heterochronic gene lin-29 coordinates the vulval-uterine-epidermal connections.
MedLine Citation:
PMID:  11114514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The development of a connection between the uterus and the vulva in the nematode Caenorhabditis elegans requires specification of a uterine cell called the utse, and its attachment to the vulva and the epidermal seam cells. The uterine pi cells generate the utse and uv1 cells, which also connect the uterus to the vulva. The uterine anchor cell (AC) induces the vulva through LIN-3/epidermal growth factor (EGF) signaling, and the pi cells through LIN-12/Notch signaling. Here, we report that a gene required for seam cell maturation is also required for specification of the utse and for vulval differentiation, and thus helps to coordinate development of the vulval-uterine-seam cell connection. RESULTS: We cloned the egl-29 gene, which is necessary for induction of uterine pi cells, and found it to be allelic to lin-29, which encodes a zinc finger transcription factor that is necessary for the terminal differentiation of epidermal seam cells. In the uterus, lin-29 functioned upstream of lin-12 in the induction of pi cells and was necessary to maintain expression in the AC of lag-2, which encodes a ligand for LIN-12. CONCLUSIONS: The lin-29 gene controls gene expression in the epidermal seam cells, uterus and vulva, and may help to coordinate the terminal development of these three tissues by regulating the timing of late gene expression during organogenesis.
Authors:
A P Newman; T Inoue; M Wang; P W Sternberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Current biology : CB     Volume:  10     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-29     Completed Date:  2001-02-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1479-88     Citation Subset:  IM    
Affiliation:
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. anewman@bcm.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis elegans / genetics*,  growth & development
Caenorhabditis elegans Proteins*
Cell Differentiation
Cell Fusion
DNA-Binding Proteins / chemistry,  genetics*,  metabolism*
Epidermis / cytology,  metabolism
Female
Gene Expression Regulation, Developmental*
Helminth Proteins / genetics,  metabolism
Molecular Sequence Data
Mutation
Transcription Factors / chemistry,  genetics*,  metabolism*
Uterus / abnormalities,  cytology,  growth & development,  metabolism
Vulva / abnormalities,  cytology,  growth & development,  metabolism
Grant Support
ID/Acronym/Agency:
GM57462/GM/NIGMS NIH HHS; HD23690/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/DNA-Binding Proteins; 0/Helminth Proteins; 0/LIN-29 protein, C elegans; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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