Document Detail

Caenorhabditis elegans and Panagrellus redivivus: enzyme-mediated modification of chemotaxis.
MedLine Citation:
PMID:  6500000     Owner:  NLM     Status:  MEDLINE    
Treatment with mannosidase or sialidase completely inhibited chemotactic responses of Caenorhabditis elegans wild type, C. elegans mutants CB1377 (daf-6)X and CB1379 (che-3)I, and Panagrellus redivivus to a source of attractants. Trypsin (EC3.4.21.4) caused a partial reduction in the level of chemoresponse. Normal chemotaxis was renewed within 20 hr following exposure to the enzymes. Other enzymes tested had no effect. Experimental and supporting evidence is presented that behavioral modification resulted from functional impairments to receptors located within chemosensory sensilla.
H B Jansson; A Jeyaprakash; R A Damon; B M Zuckerman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental parasitology     Volume:  58     ISSN:  0014-4894     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1984-12-31     Completed Date:  1984-12-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  270-7     Citation Subset:  IM    
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MeSH Terms
Caenorhabditis / drug effects,  physiology*
Chemoreceptor Cells / analysis,  physiology*
Chemotaxis / drug effects*
Hydrolases / pharmacology*
Mannosidases / pharmacology
Models, Biological
Movement / drug effects
Nematoda / drug effects,  physiology*
Neuraminidase / pharmacology
Trypsin / pharmacology
Grant Support
1-AG-9-2113/AG/NIA NIH HHS
Reg. No./Substance:
EC 3.-/Hydrolases; EC 3.2.1.-/Mannosidases; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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