Document Detail

Cadmium toxicity in plants: is there any analogy to its carcinogenic effect in mammalian cells?
MedLine Citation:
PMID:  16333748     Owner:  NLM     Status:  MEDLINE    
Cadmium is a heavy metal, which is classified as a human carcinogen and is known to be toxic to plants. However, plants do not respond to this metal by massive cell proliferation. In this review the various aspects of cadmium toxicity in plants are compared to related processes in mammalian cells. The following issues are discussed: cellular uptake of Cd ions, their intracellular transport, the effects on cellular signaling, nucleic acids and proteins, modification of gene expression, cell cycle control and apoptosis. Reviewed data suggest that such features as: ability to remove the oxidized proteins, slightly different regulation of cell cycle genes, specific pattern of apoptosis, makes plants resistant to Cd(2+)-induced uncontrolled cell proliferation.
Joanna Deckert
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine     Volume:  18     ISSN:  0966-0844     ISO Abbreviation:  Biometals     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208478     Medline TA:  Biometals     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  475-81     Citation Subset:  IM    
Laboratory of Plant Ecophysiology, Department of Biology, A.Mickiewicz University, Al. Niepodleg?o?ci 14, 61-713 Pozna?, Poland.
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MeSH Terms
Apoptosis / drug effects,  physiology
Cadmium / toxicity*
Carcinogens / toxicity*
Cell Proliferation / drug effects
Cell Transformation, Neoplastic / drug effects*
Gene Expression Regulation / drug effects
Plants / drug effects*
Signal Transduction / drug effects,  physiology
Reg. No./Substance:
0/Carcinogens; 7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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