| Cadmium toxicity in plants: is there any analogy to its carcinogenic effect in mammalian cells? | |
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MedLine Citation:
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PMID: 16333748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cadmium is a heavy metal, which is classified as a human carcinogen and is known to be toxic to plants. However, plants do not respond to this metal by massive cell proliferation. In this review the various aspects of cadmium toxicity in plants are compared to related processes in mammalian cells. The following issues are discussed: cellular uptake of Cd ions, their intracellular transport, the effects on cellular signaling, nucleic acids and proteins, modification of gene expression, cell cycle control and apoptosis. Reviewed data suggest that such features as: ability to remove the oxidized proteins, slightly different regulation of cell cycle genes, specific pattern of apoptosis, makes plants resistant to Cd(2+)-induced uncontrolled cell proliferation. |
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Authors:
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Joanna Deckert |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine Volume: 18 ISSN: 0966-0844 ISO Abbreviation: Biometals Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-04-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208478 Medline TA: Biometals Country: Netherlands |
Other Details:
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Languages: eng Pagination: 475-81 Citation Subset: IM |
Affiliation:
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Laboratory of Plant Ecophysiology, Department of Biology, A.Mickiewicz University, Al. Niepodleg?o?ci 14, 61-713 Pozna?, Poland. jagoda@amu.edu.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects, physiology Cadmium / toxicity* Carcinogens / toxicity* Cell Proliferation / drug effects Cell Transformation, Neoplastic / drug effects* Gene Expression Regulation / drug effects Humans Plants / drug effects* Signal Transduction / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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