Document Detail

Cadmium blood/urine levels and blood pressure in workers occupationally exposed to urban stressor.
MedLine Citation:
PMID:  23193898     Owner:  NLM     Status:  In-Process    
BACKGROUND: Cadmium (Cd) is a metal, which induces hypertension in animals. This may not be relevant to the human population because the number of studies is inconsistent.
OBJECTIVE: Our aim is to identify an association between levels of blood/urinary cadmium and blood pressure in a group of employees of the municipal police assigned to outdoor activities.
MATERIALS AND METHODS: 349 subjects of both sexes were enrolled and sorted on the basis of gender, job function and smoking habit. Blood and urinary cadmium levels and blood pressure readings were collected for each subject. The data were subjected to statistical evaluation. Pearson correlation coefficient between the variables and a linear regression curve was drawn. After eliminating the confounding factors, the multiple linear regression analysis assessed statistical differences. Associations were considered significant at p < 0.05.
RESULTS AND CONCLUSIONS: The Pearson correlation showed a positive association between urinary cadmium levels and blood pressure especially for groups of women and non-smokers. The simple and multiple linear regression and t-tests confirmed these associations and underlined the influence cadmium has on diastolic blood pressure, higher than systolic blood pressure. No association was found between blood cadmium and blood pressure. In conclusion, we can say that there is a statistically significant association between urinary cadmium and diastolic blood pressure, supporting the hypothesis that cadmium has a long-term effect on diastolic blood pressure (BP).
T Caciari; A Sancini; F Tomei; L Antetomaso; G Tomei; B Scala; F Sinibaldi; C Di Pastena; G Andreozzi; N Nardone; M P Schifano; P Corbosiero; A Capozzella; S De Sio; M Ciarrocca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annali di igiene : medicina preventiva e di comunità     Volume:  24     ISSN:  1120-9135     ISO Abbreviation:  Ann Ig     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002865     Medline TA:  Ann Ig     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  417-28     Citation Subset:  IM    
Department of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine, Sapienza University of Rome, Italy.
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