Document Detail

Cadmium-induced teratogenicity in lizard embryos: correlation with metallothionein gene expression.
MedLine Citation:
PMID:  20888429     Owner:  NLM     Status:  In-Process    
Cadmium teratogenic effects and metallothionein expression were studied in tissues of lizard embryos at different stages of development. Incubation of eggs in cadmium contaminated soil had no effect on embryo survival, but strongly affected cranial morphogenesis. Cytological analyses demonstrated abnormalities in the development of proencephalic vesicles, mesencephalon and eyes. No defects were observed in somite or limb development. Northern blot analysis demonstrated that MT expression was much stronger in embryos developed in cadmium contaminated soil. In situ hybridization showed an early induction of MT gene expression in developing liver and gut, whereas in brain and eyes the spatial and temporal localization of MT transcripts did not change. A possible correlation between inability to induce MT expression and abnormalities observed in the head region of lizard developing embryos is suggested.
Palma Simoniello; Chiara Maria Motta; Rosaria Scudiero; Francesca Trinchella; Silvana Filosa
Related Documents :
15723789 - Cell divisions in the drosophila embryonic mesoderm are repressed via posttranscription...
16825609 - More than 40,000 transcripts, including novel and noncoding transcripts, in mouse embry...
19959469 - Sp2 is a maternally inherited transcription factor required for embryonic development.
18653179 - Antifreeze protein gene expression in winter flounder pre-hatch embryos: implications f...
23876699 - Expression of pisum sativum psao3 gene, which encodes an aldehyde oxidase utilizing abs...
19921249 - The expression of orysa;cycb1;1 is essential for endosperm formation and causes embryo ...
23609909 - A cell wall extract from piriformospora indica promotes tuberization in potato (solanum...
9166699 - Expression of messenger ribonucleic acid (mrna) encoding 3beta-hydroxysteroid dehydroge...
18792679 - The phoq/phop regulatory network of salmonella enterica.
Publication Detail:
Type:  Journal Article     Date:  2010-10-01
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  153     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Biological Sciences, Evolutionary and Comparative Section, University Federico II, Naples, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Exposure to tebuconazol in rice field and laboratory conditions induces oxidative stress in carp (Cy...
Next Document:  Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM e...