Document Detail


Cadmium in human lung tissue.
MedLine Citation:
PMID:  2228257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 101 unselected autopsies, cadmium (Cd) in lung tissue was analyzed by means of flameless atomic absorption spectrometry (AAS). The subjects originated from Bochum (BO), Dortmund (DO), and neighbouring cities in the Ruhr District (BO/DO) as well as from Muenster (MS) and vicinity. The sample included eight persons who had died from bronchial carcinoma. The Cd concentration in lung tissue (CdL) did not show a significant age-dependency. There was only a slight increase of CdL in the age around 50. For males, the median CdL value was found to be 1.32 micrograms/g dry wt in the age group from 20-45, 1.48 micrograms/g dry wt from 45-65, and 0.64 micrograms/g dry wt greater than 65 (the corresponding means and standard deviations were 1.48 +/- 1.22, 1.73 +/- 1.42, and 1.18 +/- 1.27 micrograms/g dry wt). CdL in men was twice that in women. There were no differences between the two regions (BO/DO:MS) examined. CdL of the bronchial carcinoma cases were mostly clearly above the expected level, often similar to the Cr and Ni concentration of the same specimens. Besides the amount of inhaled metal aerosols, insufficient lung clearance may play a leading role for their retention in lung parenchyma. However, with regard to the determination of causality between uptake and disease the data are difficult to interpret, in our study due to a lack of enough consistent and reliable data on occupation, environment, and smoking habits, and in general due to a lot of variables which, until now, cannot be sufficiently quantified.
Authors:
H Kollmeier; J Seemann; P Wittig; G Rothe; K M Müller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  62     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  1990  
Date Detail:
Created Date:  1990-12-27     Completed Date:  1990-12-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  373-7     Citation Subset:  IM    
Affiliation:
Bundesanstalt für Arbeitsschutz, Dortmund, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Cadmium / chemistry*
Environmental Exposure
Female
Germany, West / epidemiology
Humans
Infant, Newborn
Lung / chemistry*
Lung Neoplasms / chemistry*,  epidemiology,  etiology
Male
Middle Aged
Reference Values
Sex Factors
Smoking / adverse effects,  epidemiology
Spectrophotometry, Atomic
Chemical
Reg. No./Substance:
7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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