| Cadmium feeding: apparent depression of atrioventricular-his-Purkinje conduction system. | |
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MedLine Citation:
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PMID: 204158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Male rats were exposed to 0, 10 and 130 p.p.m. cadmium administered in 0.5% saline drinking water for 71 days. Biweekly records of ECGs, Hct, body weight and blood levels of cadmium were made. Rats exposed to 130 p.p.m. cadmium showed slower growth rates and declining Hct indicative of acute cadmium poisoning. At the end of the experimental period, carotid artery blood pressures and whole heart cadmium levels were determined. Although no significant blood pressure changes were observed in the experimental groups, the cadmium content of the hearts of the higher dose group was significantly higher than in the hearts of the lower dose group. The PR interval of the ECG was lengthened progressively and to the same extent in both experimental groups with continued cadmium feeding. These experiments offer evidence that the accumulation of even moderate amounts of cadmium will be manifested in marked changes in cardiac conduction without overt signs of cadmium poisoning. |
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Authors:
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S J Kopp; P L Hawley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta pharmacologica et toxicologica Volume: 42 ISSN: 0001-6683 ISO Abbreviation: Acta Pharmacol Toxicol (Copenh) Publication Date: 1978 Feb |
Date Detail:
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Created Date: 1978-04-17 Completed Date: 1978-04-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370572 Medline TA: Acta Pharmacol Toxicol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 110-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrioventricular Node / drug effects Blood Pressure / drug effects Body Weight / drug effects Bundle of His / drug effects Cadmium / administration & dosage, blood Cadmium Poisoning / physiopathology* Depression, Chemical Electrocardiography Heart Conduction System / drug effects* Hematocrit Male Myocardium / metabolism Purkinje Fibers / drug effects Rats |
| Chemical | |
Reg. No./Substance:
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7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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