Document Detail

Cadmium as hypertensive agent. Effect on ion excretion in rats.
MedLine Citation:
PMID:  7904909     Owner:  NLM     Status:  MEDLINE    
1. Sodium, K and Cl excretion and changes in blood volume were studied after parenteral injection of Cd2+ (1 mumol/100 g body weight) in intact and adrenalectomized rats. 2. The final systolic arterial pressure and mean arterial pressure of adrenalectomized rats increase significantly after Cd2+ administration compared with values from control group and initial systolic arterial pressure of each group. 3. Cadmium administration induced a significant inhibition of Na+ excretion in urine and a decrease in blood volume in ADX rats compared with values from control or sham operated rats. 4. The possibility that hypertension induced by Cd may be explained by inhibition of Na excretion and changes in blood volume is discussed.
A Peña; S J Iturri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology     Volume:  106     ISSN:  0742-8413     ISO Abbreviation:  Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-03-03     Completed Date:  1994-03-03     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8310013     Medline TA:  Comp Biochem Physiol C     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
Departamento de Ciencias Ecológicas, Facultad de Ciencias, Universidad de Chile, Santiago.
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MeSH Terms
Blood Pressure / drug effects
Blood Volume / drug effects
Cadmium / pharmacology*,  toxicity
Chlorides / urine
Hypertension / chemically induced*,  physiopathology,  urine
Potassium / urine
Rats, Sprague-Dawley
Reg. No./Substance:
0/Chlorides; 7440-09-7/Potassium; 7440-43-9/Cadmium

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