Document Detail

Cabergoline reduces the early onset of ovarian hyperstimulation syndrome: a prospective randomized study.
MedLine Citation:
PMID:  19079957     Owner:  NLM     Status:  MEDLINE    
Prophylactic use of cabergoline has been associated with a decrease in the severity of ovarian hyperstimulation syndrome (OHSS). A prospective randomized study was designed to evaluate the potential of cabergoline to decrease the incidence of OHSS in high-risk patients undergoing assisted reproductive technology treatment; 166 patients with oestradiol concentrations over 4000 pg/ml on the day of human chorionic gonadotrophin (HCG) administration were evaluated. They all received 20 g routine preventive intravenous human albumin on the day of oocyte retrieval. They were then randomized into two groups: group A (n = 83) received 0.5 mg oral cabergoline per day for 3 weeks beginning on the day after oocyte retrieval, and group B (n = 83) received no medication. 'Early' OHSS was defined as being when the onset of the syndrome was initiated during the first 9 days after HCG administration, and 'late' OHSS was defined as being when the onset of the syndrome was initiated from 10 days after HCG administration. In group A, no patients progressed to 'early' OHSS and nine patients (10.8%) developed 'late' OHSS; in group B, 12 patients (15.0%) progressed to 'early' OHSS and three (3.8%) to 'late' OHSS. Although the risk of 'early' OHSS decreased significantly (P < 0.001), the risk of 'late' onset OHSS did not. The two groups presented no changes in pregnancy, implantation or miscarriages rates.
Carlos Carizza; Vicente Abdelmassih; Soraya Abdelmassih; Pedro Ravizzini; Lister Salgueiro; Paulo Tudech Salgueiro; Lin Tao Jine; Peter Nagy; Roger Abdelmassih
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  17     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-04-24     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  751-5     Citation Subset:  IM    
Roger Abdelmassih Human Reproduction Clinic and Research Centre, Avenida Brasil, 1085, São Paulo, SP, Brazil.
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MeSH Terms
Albumins / metabolism
Chorionic Gonadotropin / metabolism
Dopamine Agonists / therapeutic use*
Ergolines / therapeutic use*
Estradiol / metabolism
Fertilization in Vitro / methods
Oocytes / metabolism
Ovarian Hyperstimulation Syndrome / drug therapy*
Prospective Studies
Sperm Injections, Intracytoplasmic / methods
Treatment Outcome
Reg. No./Substance:
0/Albumins; 0/Chorionic Gonadotropin; 0/Dopamine Agonists; 0/Ergolines; 50-28-2/Estradiol; LL60K9J05T/cabergoline

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