| Ca2+ signalling: a new route to NAADP. | |
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MedLine Citation:
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PMID: 18333834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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NAADP (nicotinic acid-adenine dinucleotide phosphate) is a derivative of NADP (nicotinamide-adenine dinucleotide phosphate), which differs by the presence of a nicotinic acid instead of a nicotinamide moiety. This small structural difference makes NAADP one of the most powerful second messengers known, able to mobilize intracellular Ca2+ in a wide range of cellular models, ranging from invertebrates to mammals. Despite this, our understanding of NAADP homoeostasis, metabolism and physiological action is still limited. A new report by Vasudevan and colleagues in this issue of the Biochemical Journal provides important new data by describing a new synthetic activity in sperm cells which may turn out to represent the most physiologically relevant route to this second messenger. |
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Authors:
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Guy A Rutter; Elisa A Bellomo |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Biochemical journal Volume: 411 ISSN: 1470-8728 ISO Abbreviation: Biochem. J. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-12 Completed Date: 2008-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: England |
Other Details:
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Languages: eng Pagination: e1-3 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, Division of Medicine, Sir Alexander Fleming Building, Imperial College, London, Exhibition Road, London SW7 2AZ, UK. g.rutter@imperial.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Signaling* Humans Metabolic Networks and Pathways NADP / analogs & derivatives*, biosynthesis, metabolism Second Messenger Systems |
| Chemical | |
Reg. No./Substance:
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53-59-8/NADP; 5502-96-5/NAADP |
| Comments/Corrections | |
Comment On:
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Biochem J. 2008 Apr 1;411(1):63-70
[PMID:
18215126
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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