Document Detail

Ca2+ signalling: a new route to NAADP.
MedLine Citation:
PMID:  18333834     Owner:  NLM     Status:  MEDLINE    
NAADP (nicotinic acid-adenine dinucleotide phosphate) is a derivative of NADP (nicotinamide-adenine dinucleotide phosphate), which differs by the presence of a nicotinic acid instead of a nicotinamide moiety. This small structural difference makes NAADP one of the most powerful second messengers known, able to mobilize intracellular Ca2+ in a wide range of cellular models, ranging from invertebrates to mammals. Despite this, our understanding of NAADP homoeostasis, metabolism and physiological action is still limited. A new report by Vasudevan and colleagues in this issue of the Biochemical Journal provides important new data by describing a new synthetic activity in sperm cells which may turn out to represent the most physiologically relevant route to this second messenger.
Guy A Rutter; Elisa A Bellomo
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Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Biochemical journal     Volume:  411     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  e1-3     Citation Subset:  IM    
Department of Cell Biology, Division of Medicine, Sir Alexander Fleming Building, Imperial College, London, Exhibition Road, London SW7 2AZ, UK.
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MeSH Terms
Calcium Signaling*
Metabolic Networks and Pathways
NADP / analogs & derivatives*,  biosynthesis,  metabolism
Second Messenger Systems
Reg. No./Substance:
53-59-8/NADP; 5502-96-5/NAADP
Comment On:
Biochem J. 2008 Apr 1;411(1):63-70   [PMID:  18215126 ]

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