Document Detail


Ca2(+)-dependent and independent mechanisms of sustained contraction in vascular smooth muscle of rat aorta.
MedLine Citation:
PMID:  2110273     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Norepinephrine (NE), prostaglandin F2 alpha (PG), 12-deoxyphorbol 13-isobutyrate (DPB) and high K+ induced sustained increase in cytosolic Ca2+ [( Ca2+]i) and muscle tension in rat aorta. Verapamil, at the concentration which abolished the high K(+)-induced changes, also abolished the increase in [Ca2+]i due to NE, PG and DPB although contractions were only partially inhibited. Excess EGTA further decreased [Ca2+]i although a part of the contraction was not inhibited. These results indicate that the sustained contractions induced by NE, PG and DPB are due to increase in [Ca2+]i, increase in Ca2+ sensitivity of contractile elements, and a Ca2(+)-independent mechanism.
Authors:
H Ozaki; T Ohyama; K Sato; H Karaki
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  52     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-07     Completed Date:  1990-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
Affiliation:
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Thoracic / physiology
Calcium / physiology*
Cytosol / drug effects,  metabolism
Dinoprost / pharmacology
Egtazic Acid / pharmacology
Male
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / physiology*
Norepinephrine / pharmacology
Phorbol Esters / pharmacology
Potassium / pharmacology
Rats
Rats, Inbred Strains
Verapamil / pharmacology
Chemical
Reg. No./Substance:
0/Phorbol Esters; 25090-74-8/12-deoxyphorbol 13-isobutyrate; 51-41-2/Norepinephrine; 52-53-9/Verapamil; 551-11-1/Dinoprost; 67-42-5/Egtazic Acid; 7440-09-7/Potassium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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