| CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. | |
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MedLine Citation:
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PMID: 21609829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The assembly and maturation of neural circuits require a delicate balance between synapse formation and elimination. The cellular and molecular mechanisms that coordinate synaptogenesis and synapse elimination are poorly understood. In C. elegans, DD motoneurons respecify their synaptic connectivity during development by completely eliminating existing synapses and forming new synapses without changing cell morphology. Using loss- and gain-of-function genetic approaches, we demonstrate that CYY-1, a cyclin box-containing protein, drives synapse removal in this process. In addition, cyclin-dependent kinase-5 (CDK-5) facilitates new synapse formation by regulating the transport of synaptic vesicles to the sites of synaptogenesis. Furthermore, we show that coordinated activation of UNC-104/Kinesin3 and Dynein is required for patterning newly formed synapses. During the remodeling process, presynaptic components from eliminated synapses are recycled to new synapses, suggesting that signaling mechanisms and molecular motors link the deconstruction of existing synapses and the assembly of new synapses during structural synaptic plasticity. |
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Authors:
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Mikyoung Park; Shigeki Watanabe; Vivian Yi Nuo Poon; Chan-Yen Ou; Erik M Jorgensen; Kang Shen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuron Volume: 70 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-25 Completed Date: 2011-08-16 Revised Date: 2012-12-04 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 742-57 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biology, Stanford University, CA 94305, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / physiology* Cyclin-Dependent Kinase 5 / physiology* Cyclins / physiology* Nerve Net / physiology* Neuronal Plasticity / physiology* Synapses / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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5R01 NS048392/NS/NINDS NIH HHS; R01 NS034307-18/NS/NINDS NIH HHS; R01 NS048392/NS/NINDS NIH HHS; R01 NS048392-07/NS/NINDS NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/CCNY protein, human; 0/Caenorhabditis elegans Proteins; 0/Cyclins; EC 2.7.11.22/Cyclin-Dependent Kinase 5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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