| CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men. | |
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MedLine Citation:
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PMID: 19812606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cytochrome P-450 3A5 (CYP3A5) gene has recently been implicated in renal sodium reabsorption and blood pressure regulation. The genetic effect of CYP3A5*1 (expressor) and *3 (reduced-expressor) variants on blood pressure has been studied in African Americans and Caucasians, but not yet in the Asian population. In this cross-sectional study, 238 Japanese male workers were examined to determine whether CYP3A5 *1*3 affects the blood pressure level, taking daily salt intake into account as a potential gene-environment interaction. The A6986G polymorphism was determined by melting curve analysis, and the salt intake level was inferred from spot urine specimen by calculating 24-h urinary sodium excretion. CYP3A5 *1*3 per se had no association with systolic blood pressure (SBP) and only a weak association was detected for diastolic blood pressure (DBP) (*1/*1 vs *3/*3, P=0.038), which was strengthened after adjustment with age and body mass index (*1/*1 vs*3/*3, P=0.007; *1/*1 vs*1/*3, P=0.045). Significant interactions between the genotype and salt intake were observed in both SBP (P=0.046) and DBP (P=0.003). SBP and DBP were significantly associated with the level of salt intake in*3/*3 (P<0.001) but not in *1 carriers. *1carrier had higher blood pressure than *3/*3, but only in those with low salt intake. These results suggest that CYP3A5 variants may be a determinant of salt sensitivity of blood pressure in Japanese men. |
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Authors:
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L Zhang; K Miyaki; W Wang; M Muramatsu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-08 |
Journal Detail:
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Title: Journal of human hypertension Volume: 24 ISSN: 1476-5527 ISO Abbreviation: J Hum Hypertens Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-15 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 345-50 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Youanmenwai, Beijing, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects*, physiology Cross-Sectional Studies Culture Cytochrome P-450 CYP3A / genetics* Diet Gene Frequency / genetics Genotype Humans Hypertension / ethnology, genetics, physiopathology Japan Male Middle Aged Polymorphism, Genetic / genetics* Sodium Chloride, Dietary / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Sodium Chloride, Dietary; EC 1.14.14.1/CYP3A5 protein, human; EC 1.14.14.1/Cytochrome P-450 CYP3A |
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