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CYP3A4 genetic polymorphisms predict cyclosporine-related clinical events in Chinese renal transplant recipients.
MedLine Citation:
PMID:  23217392     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Cyclosporin A (CsA) is a substrate of both cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp), some of the single nucleotide polymorphisms (SNPs) in these genes are associated with interindividual variations in CsA pharmacokinetics. We studied the influence of these SNPs on the incidence of rejection and CsA nephrotoxicity, as well as pneumonia within one year after renal transplant and post-transplantation diabetes mellitus (PTDM), in order to find whether genetic evaluation may help to identify patients at risk and to modulate CsA therapy to optimize graft and patient outcomes.
METHODS: A total of 208 renal transplant recipients receiving CsA were genotyped for ABCB1 (C1236T, G2677T/A, and C3435T), CYP3A4*1G, and CYP3A5*3 by direct sequencing method. Retrospective case control study was utilized to identify the association between CYP3A4*1G, CYP3A5*3, ABCB1 genetic polymorphisms and CsA-related outcomes.
RESULTS: The patients with a CYP3A4*1G/*1G genotype were found to have a higher incidence of acute rejection compared with those with CYP3A4*1/*1.
CONCLUSION: CYP3A4*1G/*1G genotype predict increased risk of acute rejection, so genetic evaluation may partly help to identify patients at risk and to modulate CsA therapy to optimize graft and patient outcomes.
Yu-Yuan Wang; Ming Zhang; Fu-Ming Lu; Zheng Jiao; Xiao-Yan Qiu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  125     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  4233-8     Citation Subset:  IM    
Department of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China.
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