| CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans. | |
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MedLine Citation:
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PMID: 21135868 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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CYP2D6 genotype and debrisoquine metabolic ratio (MR) were analyzed in 133 Nicaraguan Mestizos (NMs) and 260 Cubans divided into Cuban Mestizos (CMs) and White Cubans (WCs). The frequencies of poor metabolizers (MR12.6) were 6% in NMs, 3.9% in CMs and 5.3% in WCs. The frequencies of ultrarapid metabolizers (MR0.1) were 0% in NMs, 2.3% in CMs and 5.3% in WCs. Mean (±s.d.) MR among extensive metabolizers (MR<12.6) was higher in NMs (1.5±1.6; n=118) than in CMs (1.0±1.3; n=124; P<0.001) and WCs (0.7±1.0; n=124; P<0.001). MR correlated with the 'activity score' of CYP2D6 genotypes (P<0.05; r=-0.55). Mean MR was higher among NMs than WCs and CMs for groups classified as 1 (P<0.05) or 2 (P<0.01) 'activity score'. In addition, mean (±s.d.) MR was higher among subjects carrying CYP2D6*17 than in CYP2D6 wt/wt (P<0.001). The CYP2D6*10 allele was higher in NMs (3.1%) than in CMs (0.8%; P<0.05) and WCs (0.4%; P<0.05). CYP2D6*17 allele was higher in CMs (10.2%) than WC (2.7%; P<0.005) and NMs (0%). Thus, the variability in CYP2D6 phenotypes found may be related to differences in allele frequency among groups (that is, CYP2D6*10 and *17 highest in NMs and CMs, respectively). However, the influence of environmental factors or alleles different than those studied here cannot be ruled out. |
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Authors:
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A Llerena; P Dorado; R Ramírez; I González; M Alvarez; E M Peñas-Lledó; B Pérez; L R Calzadilla |
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Publication Detail:
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Type: Journal Article Date: 2010-12-07 |
Journal Detail:
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Title: The pharmacogenomics journal Volume: 12 ISSN: 1473-1150 ISO Abbreviation: Pharmacogenomics J. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101083949 Medline TA: Pharmacogenomics J Country: United States |
Other Details:
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Languages: eng Pagination: 176-83 Citation Subset: IM |
Affiliation:
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CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, Badajoz, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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