Document Detail

CYP2C9*3 Loss-of-Function Allele Is Associated With Acute Upper Gastrointestinal Bleeding Related to the Use of NSAIDs Other Than Aspirin.
MedLine Citation:
PMID:  20445534     Owner:  NLM     Status:  MEDLINE    
Nonsteroidal anti-inflammatory drugs (NSAIDs), other than aspirin, are to some extent metabolized by cytochrome P450 2C9 (CYP2C9). The CYP2C9 359Leu (CYP2C9*3) loss-of-function allele could be a risk factor for acute upper gastrointestinal bleeding (AUGIB) related to the use of NSAIDs other than aspirin. To test this hypothesis, we performed a prospective, multicenter, case-case study in patients hospitalized for AUGIB related to the use of NSAIDs. A total of 131 patients had been treated with aspirin and 57 patients had been treated with an NSAID other than aspirin (non-ASP). In the aspirin group, 12 patients (9.2%) had the CYP2C9 359Leu allele as compared with 19 (33.3%) in the non-ASP group (odds ratio (OR) = 5.0; 95% confidence interval 2.2-11.1, P < 0.0001). In a multivariate analysis, CYP2C9 359Leu remained associated with the non-ASP group (OR = 7.2 (2.6-20.3), P = 0.0002) even though 40% of these patients were under treatment with antiulcer drugs at the time of admission. Therefore the results of the study support the hypothesis that the CYP2C9 359Leu allele is a robust risk factor for AUGIB related to the use of NSAIDs other than aspirin.
N Carbonell; C Verstuyft; J Massard; A Letierce; C Cellier; L Deforges; F Saliba; J C Delchier; L Becquemont
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-05-05
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  87     ISSN:  1532-6535     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-20     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-8     Citation Subset:  AIM; IM    
Hepatology Department, Assistance Publique H?pitaux de Paris, Saint-Antoine Hospital, University Pierre et Marie Curie, Paris, France.
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*,  metabolism
Anti-Ulcer Agents / therapeutic use
Aryl Hydrocarbon Hydroxylases / genetics*
Aspirin / adverse effects*
Case-Control Studies
Gastrointestinal Hemorrhage / chemically induced*,  genetics
Middle Aged
Multivariate Analysis
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Anti-Ulcer Agents; 50-78-2/Aspirin; EC Hydrocarbon Hydroxylases; EC protein, human

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