| CYP2C8 Polymorphism Frequencies Among Han, Uighur, Hui, and Mongolian Chinese Populations. | |
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MedLine Citation:
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PMID: 23336573 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: To determine the allele frequency of three codon-changing variants (CYP2C8*2, CYP2C8*3, and CYP2C8*4) in the Han, Uighur, Hui, and Mongolian Chinese populations, and compare genetic polymorphism differences between the Han and minority Chinese ethnicities. Methods: Five hundred seventy four healthy unrelated volunteers from four major nationalities (Han: 136; Uighur: 153; Hui: 158; Mongolian: 127) in China were recruited. The study was approved by the local research ethics committee. DNA was extracted from peripheral leukocytes using a standard protocol. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was developed to detect three alleles of CYP2C8. PCR results were confirmed by subsequent direct DNA sequencing. Results: The three minorities showed the CYP2C8 polymorphism with an allele frequency as follows: the allele frequencies of CYP2C8*2, CYP2C8*3, and CYP2C8*4 were 0.33%, 2.94%, and 2.29% in Uighur; 0.39%, 1.57%, and 1.18% in Mongolian, and 0%, 1.58%, and 0.63% in Hui, respectively. For Han, CYP2C8*2, CYP2C8*3, and CYP2C8*4 were absent. Conclusion: To the best of our knowledge, the current study described polymorphisms of CYP2C8 in Chinese minorities for the first time. The results showed that there were significant ethnic differences in the distribution of CYP2C8 in the Han and three minorities, that is, the Uighur, Hui, and Mongolian Chinese populations. |
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Authors:
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Xiujun Wu; Jinliang Zuo; Tao Guo; Li Yuan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Genetic testing and molecular biomarkers Volume: 17 ISSN: 1945-0257 ISO Abbreviation: Genet Test Mol Biomarkers Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101494210 Medline TA: Genet Test Mol Biomarkers Country: United States |
Other Details:
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Languages: eng Pagination: 104-8 Citation Subset: IM |
Affiliation:
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1 Department of Pharmacy, Shenyang Northern Hospital , Shenyang, China . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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