| CYP2B6 983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea: implications for HIV/AIDS treatment. | |
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MedLine Citation:
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PMID: 17391322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To determine the prevalence of the novel CYP2B6 functional polymorphism 983T>C in Papua New Guinea where HIV/AIDS poses a significant health problem. METHOD: We genotyped Papua New Guineans (PNG, n = 174), West Africans (WA, n = 170), and North Americans (NA, n = 361). RESULTS: The polymorphism was absent in PNG, while its overall frequency was 4.7% in WA. Among NA, the polymorphism was present in African-Americans (7.5%) and Hispanic-Americans (1.1%) but not in Caucasian-Americans and Asian-Americans. Haplotype analysis indicated that 983T>C was present alone as the CYP2B6*18 allele in WA and African-Americans. CONCLUSIONS: Significant interethnic differences occur at the CYP2B6 locus, which may influence treatment outcomes with efavirenz. |
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Authors:
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Rajeev K Mehlotra; Moses J Bockarie; Peter A Zimmerman |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-03-28 |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 64 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-24 Completed Date: 2008-01-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 391-5 Citation Subset: IM |
Affiliation:
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Center for Global Health and Diseases, Case Western Reserve University, School of Medicine, Cleveland, OH, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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drug therapy,
genetics African Americans Alleles Anti-HIV Agents / therapeutic use Aryl Hydrocarbon Hydroxylases / genetics* Benzoxazines / therapeutic use Genotype HIV Infections / drug therapy Haplotypes Humans Oxidoreductases, N-Demethylating / genetics* Papua New Guinea / ethnology Polymorphism, Single Nucleotide* Population Groups* United States / ethnology |
| Grant Support | |
ID/Acronym/Agency:
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AI 52312/AI/NIAID NIH HHS; AI-36478/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Benzoxazines; 154635-17-3/efavirenz; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/S-mephenytoin N-demethylase; EC 1.5.-/Oxidoreductases, N-Demethylating |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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