Document Detail

CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers.
MedLine Citation:
PMID:  23462429     Owner:  NLM     Status:  MEDLINE    
Variation in the CYP2A6 gene, which decreases the rate of nicotine metabolic inactivation, is associated with higher adult smoking cessation rates during clinical trials. We hypothesized that slow metabolism is associated with increased quitting during adolescence. White adolescent smokers (N=308, aged 12-17, 36.3% male) from a cohort study were genotyped for CYP2A6, resulting in 7.8% slow, 14.0% intermediate and 78.2% normal metabolizers. Overall, 144 smokers quit smoking, as indicated by being abstinent for at least 12 months. In logistic regression analyses, the odds ratio for quitting was 2.25 (95% confidence interval 1.05, 4.80; P=0.037) for slow metabolizers relative to normal metabolizers. A linear trend toward increased quitting with decreasing CYP2A6 activity was also observed (odds ratio=1.44, 95% confidence interval 1.02, 2.01; P=0.034). Thus, CYP2A6 slow metabolism is associated with increased adolescent smoking cessation, indicating that even early in the smoking history, genetic variation is influencing smoking cessation.
Meghan J Chenoweth; Jennifer O'Loughlin; Marie-Pierre Sylvestre; Rachel F Tyndale
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacogenetics and genomics     Volume:  23     ISSN:  1744-6880     ISO Abbreviation:  Pharmacogenet. Genomics     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-06     Completed Date:  2013-09-04     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101231005     Medline TA:  Pharmacogenet Genomics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-5     Citation Subset:  IM    
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MeSH Terms
Aryl Hydrocarbon Hydroxylases / genetics*
European Continental Ancestry Group
Genetic Variation
Nicotine / genetics,  metabolism*
Smoking / genetics*
Smoking Cessation*
Grant Support
DA020830/DA/NIDA NIH HHS; TMH-109787//Canadian Institutes of Health Research; U01 DA020830/DA/NIDA NIH HHS
Reg. No./Substance:
54-11-5/Nicotine; EC 1.14.13.-/coumarin 7-hydroxylase; EC Hydrocarbon Hydroxylases

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