Document Detail

CYP1A1 Gene Polymorphisms: Modulator of Genetic Damage in Coal-Tar Workers.
MedLine Citation:
PMID:  22994769     Owner:  NLM     Status:  In-Data-Review    
Aim: It is well known that polycyclic aromatic hydrocarbons (PAHs) such as benzo (a) pyrene have carcinogenic properties and may cause many types of cancers in human populations. Genetic susceptibility might be due to variation in genes encoding for carcinogen metabolizing enzymes, such as cytochrome P-450 (CYP450). Our study aimed to investigate the effect of genetic polymorphisms of CYP1A1 (m1 and m2) on genetic damage in 115 coal- tar workers exposed to PAHs in their work place. Methods: Genetic polymorphisms of CYP1A1 were determined by the PCR-RFLP method. Comet and buccal micronucleus assays were used to evaluate genetic damage among 115 coal tar workers and 105 control subjects. Results: Both CYP1A1 m1 and CYP1A1 m2 heterozygous and homozygous (wt/mt+mt/mt) variants individually as well as synergistically showed significant association (P<0.05) with genetic damage as measured by tail moment (TM) and buccal micronuclei (BMN) frequencies in control and exposed subjects. Conclusion: In our study we found significant association of CYP1A1 m1 and m2 heterozygous (wt/mt) +homozygous (mt/mt) variants with genetic damage suggesting that these polymorphisms may modulate the effects of PAH exposure in occupational settings.
Shiv Kumar Giri; Anita Yadav; Anil Kumar; Kapil Dev; Sachin Gulati; Ranjan Gupta; Neeraj Aggarwal; Sanjeev Kumar Gautam
Related Documents :
25179879 - C771g (his241gln) polymorphism of mlxipl gene, tg levels and coronary artery disease: a...
22627569 - Report on the p.ser489x (p.ser489*) cftr mutation, a variant with severe associated phe...
16390439 - A spontaneous genomic deletion in listeria ivanovii identifies lipi-2, a species-specif...
21099189 - Genetically diverse group c rotaviruses cause sporadic infection in korean calves.
16926229 - Genetic structure in aquatic bladderworts: clonal propagation and hybrid perpetuation.
728069 - Genetic and molecular analysis of nonrandom dimer assembly of the creatine kinase isozy...
1872889 - N-acetyltransferase polymorphism. comparison of phenotype and genotype in humans.
15150539 - Analysis of genetic diversity and conservation priorities in iberian pigs based on micr...
8176269 - Absence of p53 gene mutations in cutaneous melanoma.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of cancer prevention : APJCP     Volume:  13     ISSN:  1513-7368     ISO Abbreviation:  Asian Pac. J. Cancer Prev.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130625     Medline TA:  Asian Pac J Cancer Prev     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  3409-16     Citation Subset:  IM    
Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, India E-mail :
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  RALY RNA Binding Protein-like Reduced Expression is Associated with Poor Prognosis in Clear Cell Ren...
Next Document:  Lack of Association Between LIG4 Gene Polymorphisms and the Risk of Breast Cancer: A HuGE Review and...