| CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China. | |
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MedLine Citation:
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PMID: 12854128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To characterize cytochrome P4501A1 (CYP1A1), glutathione S-transferases (GSTs) and microsomal epoxide hydrolase (mEH) polymorphisms in Chinese esophageal cancer patients. METHODS: Multiplex polymerase chain reaction (PCR) and PCR based restriction fragment length polymorphisms (PCR-RFLP) were used to detect polymorphism changes of CYP, GSTs and mEH on esophageal cancerous and precancerous lesions as well as in case control group. All the examination samples were obtained from Linzhou (formerly Linxian), Henan Province, the highest incidence area for esophageal cancer. RESULTS: The frequency of CYP1A1 3' polymorphism in case control group (26/38, 68 %) was significantly higher than in esophageal squamous cell carcinoma group (ESCC) (29/62, 47 %) (P<0.05). A significant difference in the incidence of mEH slow allele variant was observed between case control group (15/38, 39 %) and esophageal dysplasia group (22/32, 69 %) or ESCC group (39/62, 63 %) (P<0.05). However, no significant difference was observed among different groups in the polymorphisms of CYP1A1 exon 7, GSTM1, GSTT1, GSTP1 and mEH fast allele. CONCLUSION: The present results suggest that CYP1A1 3' polymorphism may be one of the promising protective factors and its wild gene type may be an indicator for higher susceptibility to esophageal cancer. mEH slow allele variant, associated with the progression of esophageal precancerous lesions, may contribute to the high susceptibility to esophageal carcinoma. |
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Authors:
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Li-Dong Wang; Shu Zheng; Bin Liu; Jian-Xiang Zhou; Yan-Jie Li; Ji-Xue Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 9 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-10 Completed Date: 2003-11-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1394-7 Citation Subset: IM |
Affiliation:
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Cancer Institute, Zhejiang University, Hangzhou, Zheijiang Province, China. lidong0823@sina.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Squamous Cell / epidemiology, genetics* Case-Control Studies China / epidemiology Cytochrome P-450 CYP1A1 / genetics* Epoxide Hydrolases / genetics* Esophageal Neoplasms / epidemiology, genetics* Female Genetic Predisposition to Disease / epidemiology Genotype Glutathione Transferase / genetics* Humans Incidence Male Middle Aged Polymorphism, Restriction Fragment Length |
| Grant Support | |
ID/Acronym/Agency:
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CA65871/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 1.14.14.1/Cytochrome P-450 CYP1A1; EC 2.5.1.18/Glutathione Transferase; EC 3.3.2.-/Epoxide Hydrolases |
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