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CXXC5 regulates differentiation of C2C12 myoblasts into myocytes.
MedLine Citation:
PMID:  25433557     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
CXXC5 is a member of the CXXC-type zinc-finger domain containing protein family, which is suggested to function in gene transcription, cell adhesion and cytoskeleton organization. Previous studies have revealed that CXXC5 is expressed in skeletal muscle, but whether it regulates skeletal myogenesis is yet unknown. Here, we screened for the possible signaling pathways in which CXXC5 might participate using luciferase gene reporters. The results indicated that CXXC5 significantly increased the activities of the promoters of genes involved in skeletal muscle differentiation. We therefore studied the role of CXXC5 during skeletal myogenesis in C2C12 myoblasts. Our findings suggest that overexpression of CXXC5 in C2C12 myoblasts facilitated myocyte differentiation, while RNAi interference of CXXC5 significantly inhibited the differentiation of C2C12 myoblasts. This study suggests that CXXC5 plays a significant role in regulating skeletal myogenesis.
Authors:
Guangming Li; Xiangli Ye; Xiyang Peng; Yun Deng; Wuzhou Yuan; Yongqing Li; Xiaoyang Mo; Xijun Wang; Yongqi Wan; Xianchu Liu; Tingfang Chen; Zhigang Jiang; Xiongwei Fan; Xiushan Wu; Yuequn Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-30
Journal Detail:
Title:  Journal of muscle research and cell motility     Volume:  -     ISSN:  1573-2657     ISO Abbreviation:  J. Muscle Res. Cell. Motil.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-30     Completed Date:  -     Revised Date:  2014-12-1    
Medline Journal Info:
Nlm Unique ID:  8006298     Medline TA:  J Muscle Res Cell Motil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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