Document Detail

CXC ligand 9 response to malaria during pregnancy is associated with low-birth-weight deliveries.
MedLine Citation:
PMID:  22689822     Owner:  NLM     Status:  MEDLINE    
Placental infection with Plasmodium falciparum is associated with increased levels of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-α) and gamma interferon (IFN-γ), and previous studies have associated increased levels of these cytokines with low birth weight (LBW), especially for malaria-infected primigravidae. To define the contribution of TNF-α and IFN-γ networks to placental-malaria-associated LBW, we measured chemokines induced by TNF-α and IFN-γ and related them to birth weight in a birth cohort of 782 mother-infant pairs residing in an area of P. falciparum holoendemicity in Tanzania. Among primigravidae, levels of CCL2, CXC ligand 9 (CXCL9), and CXCL13 were significantly higher during malaria infection in both the placenta and peripheral blood. Placental CXCL9 and CXCL13 levels were also higher in placental blood from secundigravidae and multigravidae. In multivariate analyses adjusted for known predictors of birth weight, malaria-infected primigravidae with placental CXCL9 levels in the lowest tertile gave birth to babies who weighed 610 g more than babies born to mothers with high CXCL9 levels. CXCL9 expression is induced by IFN-γ, and the strong association between birth weight and placental CXCL9 is consistent with previous observations relating IFN-γ to poor pregnancy outcomes.
Shu Dong; Jonathan D Kurtis; Sunthorn Pond-Tor; Edward Kabyemela; Patrick E Duffy; Michal Fried
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2012-06-11
Journal Detail:
Title:  Infection and immunity     Volume:  80     ISSN:  1098-5522     ISO Abbreviation:  Infect. Immun.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-15     Completed Date:  2012-10-24     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3034-8     Citation Subset:  IM    
Seattle Biomedical Research Institute, Seattle, Washington, USA.
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MeSH Terms
Blood Chemical Analysis
Chemokine CXCL9 / analysis,  blood*
Cohort Studies
Infant, Low Birth Weight*
Infant, Newborn
Longitudinal Studies
Malaria, Falciparum / complications*,  immunology*
Placenta / chemistry
Plasmodium falciparum*
Pregnancy Complications, Infectious / immunology*
Young Adult
Grant Support
Reg. No./Substance:
0/Chemokine CXCL9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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