Document Detail

CXCL5 limits macrophage foam cell formation in atherosclerosis.
MedLine Citation:
PMID:  23376791     Owner:  NLM     Status:  MEDLINE    
The ELR(+)-CXCL chemokines have been described typically as potent chemoattractants and activators of neutrophils during the acute phase of inflammation. Their role in atherosclerosis, a chronic inflammatory vascular disease, has been largely unexplored. Using a mouse model of atherosclerosis, we found that CXCL5 expression was upregulated during disease progression, both locally and systemically, but was not associated with neutrophil infiltration. Unexpectedly, inhibition of CXCL5 was not beneficial but rather induced a significant macrophage foam cell accumulation in murine atherosclerotic plaques. Additionally, we demonstrated that CXCL5 modulated macrophage activation, increased expression of the cholesterol efflux regulatory protein ABCA1, and enhanced cholesterol efflux activity in macrophages. These findings reveal a protective role for CXCL5, in the context of atherosclerosis, centered on the regulation of macrophage foam cell formation.
Anthony Rousselle; Fatimunnisa Qadri; Lisa Leukel; Rüstem Yilmaz; Jean-Fred Fontaine; Gabin Sihn; Michael Bader; Amrita Ahluwalia; Johan Duchene
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-08
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-05-13     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1343-7     Citation Subset:  AIM; IM    
Max Delbrück Center for Molecular Medicine, Berlin, Germany.
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MeSH Terms
ATP-Binding Cassette Transporters / genetics,  metabolism
Aorta / metabolism
Apolipoproteins E / deficiency,  genetics
Atherosclerosis / blood,  immunology*
Chemokine CXCL5 / genetics,  metabolism,  physiology*
Cholesterol / secretion
Endothelial Cells / metabolism
Foam Cells / immunology*,  secretion
Macrophage Activation
Mice, Inbred C57BL
Mice, Knockout
Plaque, Atherosclerotic / immunology,  pathology
RNA, Messenger / blood,  genetics
Receptors, Interleukin-8B / metabolism
Transcriptional Activation
Reg. No./Substance:
0/ATP binding cassette transporter 1; 0/Apolipoproteins E; 0/Chemokine CXCL5; 0/Cxcl5 protein, mouse; 0/RNA, Messenger; 0/Receptors, Interleukin-8B; 57-88-5/Cholesterol

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