| CXCL16 contributes to neutrophil recruitment to cerebrospinal fluid in pneumococcal meningitis. | |
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MedLine Citation:
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PMID: 20874518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we analyzed the expression and function of CXCL16 in pneumococcal meningitis. CXCL16 was found to be up‐regulated in RAW264.7 macrophages (but not in neutrophils and endothelial cells) upon pneumococcal stimulation, in the cerebrospinal fluid of patients, and in the brains as well as the cerebrospinal fluid of mice with pneumococcal meningitis. CXCL16 up‐regulation in vivo was dependent on Toll‐like receptor (TLR) 2/TLR4 and MyD88 signaling. Neutralization of CXCL16 in animals before intracisternal pneumococcal infection (using anti‐CXCL16 antibodies) resulted in reduced cerebrospinal fluid pleocytosis. In vitro, murine neutrophils expressed the CXCL16 receptor CXCR6 and showed dose‐dependant migration toward a CXCL16 gradient. Thus, this study implicates CXCL16 as an additional neutrophil chemoattractant in cerebrospinal fluid in early pneumococcal meningitis. |
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Authors:
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Bianca Woehrl; Matthias Klein; Tobias A Rupprecht; Helga Schmetzer; Barbara Angele; Hans Häcker; Georg Häcker; Hans-Walter Pfister; Uwe Koedel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 202 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1389-96 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany. Bianca.Woehrl@med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / cytology, immunology Cell Line Cerebrospinal Fluid / cytology*, immunology Chemokine CXCL6 / immunology* Endothelial Cells / immunology Gene Expression Profiling Humans Macrophages / immunology Meningitis, Pneumococcal / immunology* Mice Mice, Inbred C57BL Myeloid Differentiation Factor 88 / immunology Neutrophil Infiltration* Neutrophils / immunology* Receptors, CXCR / immunology Toll-Like Receptor 2 / immunology Toll-Like Receptor 4 / immunology |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CXCL6; 0/Cxcl16 protein, mouse; 0/Cxcr6 protein, mouse; 0/Myd88 protein, mouse; 0/Myeloid Differentiation Factor 88; 0/Receptors, CXCR; 0/Toll-Like Receptor 2; 0/Toll-Like Receptor 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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