| CXC chemokine-mediated protection against visceral leishmaniasis: involvement of the proinflammatory response. | |
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MedLine Citation:
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PMID: 19743920 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Visceral leishmaniasis, caused by the protozoan parasite Leishmania donovani, is characterized by the loss of ability of the host to generate an effective immune response. In the present study, the comparative potential of CXC chemokines, interferon-gamma-inducible protein-10 (IP-10) and interleukin-8 (IL-8) in restricting Leishmania donovani infection via the release of nitric oxide and proinflammatory cytokines was studied in an in vitro model. Nitric oxide, a crucial mediator for IP-10-mediated leishmanicidal activity, was found to be dependent on inducible nitric oxide synthase 2 (iNOS2) expression and was linked to the mitogen-activated protein kinases (MAPK) signaling pathway. Further, IP-10 was also able to abrogate the survival of Leishmania in an in vivo model of visceral leishmaniasis by restoration of Th1 cytokines and nitric oxide. Thus, this study strongly demonstrates that IP-10, like CC chemokines, is involved in rendering a protective response in visceral leishmaniasis via up-regulation of proinflammatory mediators. |
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Authors:
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Gaurav Gupta; Surajit Bhattacharjee; Sandip Bhattacharyya; Parna Bhattacharya; Anupam Adhikari; Asok Mukherjee; Suchandra Bhattacharyya Majumdar; Subrata Majumdar |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 200 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2009-10-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1300-10 Citation Subset: AIM; IM |
Affiliation:
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Division of Molecular Medicine, Bose Institute, P1/12, CIT Scheme VII-M, Kolkata, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemokines, CXC / genetics, metabolism* Female Gene Expression Regulation / physiology Leishmania donovani / physiology Leishmaniasis, Visceral / immunology* Macrophages, Peritoneal / metabolism* Male Mice Mice, Inbred BALB C Mitogen-Activated Protein Kinase Kinases / metabolism Nitric Oxide / metabolism Nitric Oxide Synthase Type II / genetics, metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Chemokines, CXC; 10102-43-9/Nitric Oxide; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 2.7.12.2/Mitogen-Activated Protein Kinase Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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