Document Detail

CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury.
MedLine Citation:
PMID:  16809547     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A functional polymorphism in the chemokine receptor CX3CR1 is associated with protection from vascular diseases including coronary artery disease and internal carotid artery occlusive disease. We investigated the mechanisms by which CX3CR1 may be involved by evaluating the inflammatory response to arterial injury in CX3CR1-deficient animals. METHODS AND RESULTS: Femoral arteries of CX3CR1-/- and wild-type (WT) mice were injured with an angioplasty guide wire. After 1, 5, 14, and 28 days, arteries were harvested and evaluated by histology, morphometry, and immunohistochemistry. Arterial injury upregulated the CX3CR1 ligand CX3CL1. In CX3CR1-/- compared with WT animals, the incidence of neointima formation was 58% lower (P=0.0017), accompanied by no difference in the area of platelet accumulation at day 1 (P=0.48) but a significant decrease in intimal monocyte infiltration at day 5 (P=0.006), vascular smooth muscle cell (VSMC) proliferation at days 5 and 14, and intimal area at day 28 (P=0.009). CONCLUSIONS: In an endothelial denudation injury model, CX3CR1 deficiency protects animals from developing intimal hyperplasia as a result of decreased monocyte trafficking to the lesion. CX3CR1 deficiency decreases VSMC proliferation and intimal accumulation either directly or indirectly as a result of defective monocyte infiltration.
Peng Liu; Sarita Patil; Mauricio Rojas; Alan M Fong; Susan S Smyth; Dhavalkumar D Patel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-06-29
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  26     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-18     Completed Date:  2006-09-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2056-62     Citation Subset:  IM    
Department of Medicine, University of North Carolina at Chapel Hill, USA.
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MeSH Terms
Cell Division
Cell Movement
Femoral Artery / injuries*,  metabolism*,  pathology
Mice, Knockout
Muscle, Smooth, Vascular / pathology,  physiopathology
Myocytes, Smooth Muscle
Platelet Function Tests
Receptors, Chemokine / deficiency*
Tunica Intima / pathology*
Wounds and Injuries / metabolism,  pathology
Grant Support
Reg. No./Substance:
0/Cx3cr1 protein, mouse; 0/Receptors, Chemokine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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