Document Detail


CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury.
MedLine Citation:
PMID:  16809547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A functional polymorphism in the chemokine receptor CX3CR1 is associated with protection from vascular diseases including coronary artery disease and internal carotid artery occlusive disease. We investigated the mechanisms by which CX3CR1 may be involved by evaluating the inflammatory response to arterial injury in CX3CR1-deficient animals. METHODS AND RESULTS: Femoral arteries of CX3CR1-/- and wild-type (WT) mice were injured with an angioplasty guide wire. After 1, 5, 14, and 28 days, arteries were harvested and evaluated by histology, morphometry, and immunohistochemistry. Arterial injury upregulated the CX3CR1 ligand CX3CL1. In CX3CR1-/- compared with WT animals, the incidence of neointima formation was 58% lower (P=0.0017), accompanied by no difference in the area of platelet accumulation at day 1 (P=0.48) but a significant decrease in intimal monocyte infiltration at day 5 (P=0.006), vascular smooth muscle cell (VSMC) proliferation at days 5 and 14, and intimal area at day 28 (P=0.009). CONCLUSIONS: In an endothelial denudation injury model, CX3CR1 deficiency protects animals from developing intimal hyperplasia as a result of decreased monocyte trafficking to the lesion. CX3CR1 deficiency decreases VSMC proliferation and intimal accumulation either directly or indirectly as a result of defective monocyte infiltration.
Authors:
Peng Liu; Sarita Patil; Mauricio Rojas; Alan M Fong; Susan S Smyth; Dhavalkumar D Patel
Related Documents :
7814607 - Chemokine expression during hepatic ischemia/reperfusion-induced lung injury in the rat...
12154677 - Prehospital rounds. the quick stop.
9160137 - Aneurysm of the radial artery following blunt trauma to the wrist.
7275287 - Arterial injuries associated with fractures of the lower limbs in childhood.
16479737 - Secondary pulmonary hypertension--diagnosis and management.
22205897 - The role of uterine artery embolization in cervical cancer - single case report.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-06-29
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  26     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-18     Completed Date:  2006-09-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2056-62     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of North Carolina at Chapel Hill, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division
Cell Movement
Femoral Artery / injuries*,  metabolism*,  pathology
Hyperplasia
Mice
Mice, Knockout
Monocytes
Muscle, Smooth, Vascular / pathology,  physiopathology
Myocytes, Smooth Muscle
Platelet Function Tests
Receptors, Chemokine / deficiency*
Tunica Intima / pathology*
Wounds and Injuries / metabolism,  pathology
Grant Support
ID/Acronym/Agency:
R01 CA098110/CA/NCI NIH HHS; R01 HL074219/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cx3cr1 protein, mouse; 0/Receptors, Chemokine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endotheli...
Next Document:  Abdominal aortic aneurysm rupture is associated with increased medial neovascularization and overexp...