| A CTLA4high genotype is associated with myasthenia gravis in thymoma patients. | |
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MedLine Citation:
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PMID: 16178018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myasthenia gravis (MG) in thymoma patients depends critically on intratumorous generation and export of mature autoreactive CD4+ T cells. Why non-MG thymomas fail to produce CD4+ T cells is unknown. We studied three single-nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4(CTLA4) gene in thymoma patients, nonthymoma early-onset MG patients, and control subjects. Surprisingly, the CTLA4high genotype +49A/A, which is protective against several autoimmune diseases, exerted a prominent predisposing effect to paraneoplastic MG in thymoma patients. The unusual disease association with a CTLA4high genotype implies a unique pathogenesis of paraneoplastic MG, with high CTLA4 levels possibly supporting the nontolerogenic selection of CD4+ T cells in MG-associated thymomas. |
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Authors:
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Wen-Yu Chuang; Philipp Ströbel; Ralf Gold; Wilfred Nix; Berthold Schalke; Reinhard Kiefer; Andreas Opitz; Erdwine Klinker; Hans K Müller-Hermelink; Alexander Marx |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 58 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-28 Completed Date: 2005-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 644-8 Citation Subset: IM |
Affiliation:
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Institute of Pathology, University of Würzburg, Würzburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antigens, CD Antigens, Differentiation / genetics*, metabolism Child Demography Female Gene Frequency Genotype Humans Male Middle Aged Myasthenia Gravis / etiology, genetics* Polymorphism, Single Nucleotide Thymoma / complications* Thymus Neoplasms / complications, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation; 0/cytotoxic T-lymphocyte antigen 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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