Document Detail

A CTLA4high genotype is associated with myasthenia gravis in thymoma patients.
MedLine Citation:
PMID:  16178018     Owner:  NLM     Status:  MEDLINE    
Myasthenia gravis (MG) in thymoma patients depends critically on intratumorous generation and export of mature autoreactive CD4+ T cells. Why non-MG thymomas fail to produce CD4+ T cells is unknown. We studied three single-nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4(CTLA4) gene in thymoma patients, nonthymoma early-onset MG patients, and control subjects. Surprisingly, the CTLA4high genotype +49A/A, which is protective against several autoimmune diseases, exerted a prominent predisposing effect to paraneoplastic MG in thymoma patients. The unusual disease association with a CTLA4high genotype implies a unique pathogenesis of paraneoplastic MG, with high CTLA4 levels possibly supporting the nontolerogenic selection of CD4+ T cells in MG-associated thymomas.
Wen-Yu Chuang; Philipp Ströbel; Ralf Gold; Wilfred Nix; Berthold Schalke; Reinhard Kiefer; Andreas Opitz; Erdwine Klinker; Hans K Müller-Hermelink; Alexander Marx
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  58     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-28     Completed Date:  2005-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  644-8     Citation Subset:  IM    
Institute of Pathology, University of Würzburg, Würzburg, Germany.
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MeSH Terms
Antigens, CD
Antigens, Differentiation / genetics*,  metabolism
Gene Frequency
Middle Aged
Myasthenia Gravis / etiology,  genetics*
Polymorphism, Single Nucleotide
Thymoma / complications*
Thymus Neoplasms / complications,  genetics*
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation; 0/cytotoxic T-lymphocyte antigen 4

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