| CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. | |
| | |
MedLine Citation:
|
PMID: 9164923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mice lacking CTLA-4 develop a fatal spontaneous lymphoproliferative disease with massive lymphocytic infiltrates and tissue destruction in many organs. CTLA-4-deficient (-/-) splenocytes and lymph node cells proliferate without added stimuli in vitro. We report here that CTLA4Ig treatment of CTLA-4 -/- mice prevents lymphoproliferation and fatal multiorgan tissue damage in vivo and proliferation of CTLA-4 -/- splenocytes and lymph node cells in vitro. Therefore, stimulation via CD28-B7 interactions appears necessary for CTLA-4 -/- T cell proliferation and the production of lymphoproliferative disease in vivo. When CTLA4Ig treatment is terminated, CTLA-4 -/- T cells become activated and lymphoproliferative disease develops. The lack of long term protective effects of CTLA4Ig treatment suggests that CTLA-4 is needed for the induction and or maintenance of tolerance. |
| | |
Authors:
|
E A Tivol; S D Boyd; S McKeon; F Borriello; P Nickerson; T B Strom; A H Sharpe |
Related Documents
:
|
3890763 - Eosinophilic granuloma. presence of okt6-positive cells and good response to intralesio... 6202133 - Immunohistochemical demonstration of s-100 protein antigen-containing cells in berylliu... 2830153 - Nerve growth factor (ngf) induced differentiation of human neuroblastoma cells. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 158 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1997 Jun |
Date Detail:
|
Created Date: 1997-06-19 Completed Date: 1997-06-19 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 5091-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigens, CD Antigens, Differentiation / administration & dosage, genetics, immunology* Cell Division / drug effects Immune Tolerance / genetics, immunology Immunoconjugates* Immunosuppressive Agents / administration & dosage Lymphoproliferative Disorders / genetics, immunology*, pathology, prevention & control Mice Mice, Knockout |
| Grant Support | |
ID/Acronym/Agency:
|
1P30AR42689/AR/NIAMS NIH HHS; P01 AI35225/AI/NIAID NIH HHS; T32 HLO7627/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD; 0/Antigens, Differentiation; 0/Immunoconjugates; 0/Immunosuppressive Agents; 0/abatacept; 0/cytotoxic T-lymphocyte antigen 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microbial products induce autoimmune disease by an IL-12-dependent pathway.
Next Document: Effects of extracellular ATP and adenosine on different thymocyte subsets: possible role of ATP-gate...