Document Detail


CTLA4 in multiple sclerosis. Lack of genetic association in a European Caucasian population but evidence of interaction with HLA-DR2 among Shanghai Chinese.
MedLine Citation:
PMID:  11239948     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study we searched for an association between multiple sclerosis (MS) and the gene encoding the cytotoxic T lymphocyte antigen 4 (CTLA4). Our experimental approach involved amplification of DNA fragments of the promoter and exon 1 of this gene containing single nucleotide polymorphisms followed by treatment of the amplified fragments with restriction enzymes for allele determination. Included in the study were 84 MS patients and 125 healthy control subjects from a population of white Caucasians. We also examined 42 MS patients and 86 healthy control subjects of Shanghai Chinese origin. Significant differences in the distribution of genotypes or haplotypes of the CTLA4 gene were not observed between MS patients and control subjects in either of the two populations (P>0.05). Moreover, we were not able to confirm a previous finding of an association between relapsing-remitting MS and the heterozygous genotype A/G of CTLA4 exon 1. There was no evidence to suggest that interaction between HLA-DR2 and CTLA4 is involved in the development of MS among European Caucasians (P>0.05). Opposed to this, analysis of the Shanghai Chinese suggested presence of such interaction (P=0.02). Our results do not support the assumption that CTLA4 influences susceptibility to MS in European Caucasians. On the other hand, they raise the possibility that the development of MS in other ethnic groups involves interaction between CTLA4 and DR2.
Authors:
H B Rasmussen; M A Kelly; D A Francis; J Clausen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  184     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-06-07     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  IM    
Affiliation:
Department of Life Sciences, Roskilde University, PO Box 260, DK-4000 Roskilde, Denmark. hbr@virgil.ruc.dk
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD
Antigens, Differentiation / genetics*
Asian Continental Ancestry Group / genetics*
CTLA-4 Antigen
Case-Control Studies
Chi-Square Distribution
Europe
European Continental Ancestry Group / genetics*
Genotype
HLA-DR2 Antigen / genetics*
Haplotypes / genetics
Humans
Immunoconjugates*
Logistic Models
Multiple Sclerosis / genetics*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation; 0/CTLA-4 Antigen; 0/CTLA4 protein, human; 0/HLA-DR2 Antigen; 0/Immunoconjugates; 7D0YB67S97/abatacept

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