| CTLA-4 regulates induction of anergy in vivo. | |
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MedLine Citation:
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PMID: 11239447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The requirement for CTLA-4 during the induction of peripheral T cell tolerance in vivo was investigated using naive TCR transgenic T cells lacking CTLA-4. CTLA-4(-/-) T cells are resistant to tolerance induction, as demonstrated by their proliferative responses, IL-2 production, and progression into the cell cycle. Following exposure to a tolerogenic stimulus in vivo and restimulation in vitro, wild-type T cells are blocked at the late G1 to S restriction point of the cell cycle. In contrast, CTLA-4(-/-) T cells enter into the S phase of the cell cycle, as shown by downregulation of p27(kip1), elevated cdk2 kinase activity, and Rb hyperphosphorylation. Thus, CTLA-4 has an essential role in determining the outcome of T cell encounter with a tolerogenic stimulus. |
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Authors:
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R J Greenwald; V A Boussiotis; R B Lorsbach; A K Abbas; A H Sharpe |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunity Volume: 14 ISSN: 1074-7613 ISO Abbreviation: Immunity Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-04-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
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Languages: eng Pagination: 145-55 Citation Subset: IM |
Affiliation:
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Immunology Research Division, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD Antigens, Differentiation / genetics, immunology* Apoptosis Cell Cycle Clonal Anergy / immunology* Cytokines / biosynthesis DNA-Binding Proteins Immune Tolerance Immunoconjugates* Interleukin-2 / biosynthesis Lymphocyte Activation Mice Mice, Inbred BALB C Mice, Knockout Mice, Transgenic T-Lymphocytes / cytology, immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AI35297/AI/NIAID NIH HHS; AI40614/AI/NIAID NIH HHS; AI41584/AI/NIAID NIH HHS; AI43552/AI/NIAID NIH HHS; F32AI10415/AI/NIAID NIH HHS; T32HL07627/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation; 0/Cytokines; 0/DNA-Binding Proteins; 0/Immunoconjugates; 0/Interleukin-2; 0/Rag2 protein, mouse; 0/V(D)J recombination activating protein 2; 0/abatacept; 0/cytotoxic T-lymphocyte antigen 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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