Document Detail


CTA combined with CT perfusion for assessing the efficacy of anti-angiogenic therapy in rabbit VX2 tumors.
MedLine Citation:
PMID:  22310524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: The aim of this study was to validate the feasibility of assessing the efficacy of antiangiogenic therapy on VX2 tumors using three-dimensional computed tomographic (CT) angiography (CTA) combined with CT perfusion.
MATERIALS AND METHODS: Forty rabbits with VX2 tumors were randomly assigned to four groups according to different doses of antiangiogenic drug, which were administered intraperitoneally daily for 14 days. In each group, 10 animals were scanned using three-dimensional CTA and CT perfusion on days 1 and 2 after the latest administration of the drug. Tumor masses were sectioned, stained by immunohistochemistry, and processed for correlation between CT imaging and histology.
RESULTS: The numbers of new tumor vessels from CTA were significantly different among the four groups (P < .001). As the dose of the drug increased, blood flow and blood volume on CT perfusion increased linearly, but the mean transit time and permeability surface-area product decreased linearly (P < .001). Immunohistochemical analyses showed that microvascular density decreased, while both luminal vascular number and mature vessel number increased linearly as the drug dose increased (P < .001). CT manifestations were correlated well with histologic findings (P < .05).
CONCLUSIONS: It is feasible to assess the efficacy of antiangiogenic therapy on VX2 tumors using three-dimensional CTA combined with CT perfusion. Three-dimensional CTA can display the morphologic changes of tumor vessels, while CT perfusion can predict the functional changes of tumor vessels after antiangiogenic therapy.
Authors:
Han Wang; Lin-Feng Zheng; Yan Feng; Xue-Qian Xie; Xiao-Ming Yang; Gui-Xiang Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Academic radiology     Volume:  19     ISSN:  1878-4046     ISO Abbreviation:  Acad Radiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-07     Completed Date:  2012-06-07     Revised Date:  2014-04-16    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 AUR. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inhibitors / administration & dosage
Angiography / methods
Animals
Cell Line, Tumor
Endostatins / administration & dosage*
Feasibility Studies
Infusions, Parenteral
Liver Neoplasms / drug therapy*,  radiography*
Neovascularization, Pathologic / drug therapy*,  radiography*
Perfusion Imaging / methods*
Rabbits
Reproducibility of Results
Sensitivity and Specificity
Subtraction Technique
Tomography, X-Ray Computed / methods*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
R01 EB012467/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Endostatins
Comments/Corrections
Erratum In:
Acad Radiol. 2014 Apr;21(4):561

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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