Document Detail


CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis.
MedLine Citation:
PMID:  10699956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Assays relying on humoral or T-cell-based recognition of tumor antigens to identify potential targets for immunotherapy have led to the discovery of a significant number of immunogenic gene products, including cancer-testis (CT) antigens predominantly expressed in cancer cells and male germ cells. The search for cancer-specific antigens has been extended via the technique of representational-difference analysis and SK-MEL-37, a melanoma cell line expressing a broad range of CT antigens. Using this approach, we have isolated CT antigen genes, genes over-expressed in cancer, e. g., PRAME and KOC, and genes encoding neuro-ectodermal markers. The identified CT antigen genes include the previously defined MAGE-A6, MAGE-A4a, MAGE-A10, CT7/MAGE-C1, as well as a novel gene designated CT10, which shows strong homology to CT7/MAGE-C1 both at cDNA and at genomic levels. Chromosome mapping localized CT10 to Xq27, in close proximity to CT7/MAGE-C1 and MAGE-A genes. CT10 mRNA is expressed in testis and in 20 to 30% of various human cancers. A serological survey identified 2 melanoma patients with anti-CT10 antibody, demonstrating the immunogenicity of CT10 in humans.
Authors:
A O Güre; E Stockert; K C Arden; A D Boyer; C S Viars; M J Scanlan; L J Old; Y T Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  85     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-22     Completed Date:  2000-03-22     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  726-32     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Affiliation:
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Antigens, Neoplasm / analysis,  genetics*
Base Sequence
Chromosome Mapping
Exons
Female
Gene Expression Regulation, Neoplastic
Humans
Introns
Male
Melanoma / genetics*
Molecular Sequence Data
Neoplasm Proteins / analysis,  chemistry,  genetics*
Organ Specificity
RNA, Messenger / genetics
Sequence Alignment
Sequence Homology, Amino Acid
Testis / metabolism
Transcription, Genetic
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/MAGEC2 protein, human; 0/Neoplasm Proteins; 0/RNA, Messenger

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