Document Detail

CT to cone-beam CT deformable registration with simultaneous intensity correction.
MedLine Citation:
PMID:  23032638     Owner:  NLM     Status:  MEDLINE    
Computed tomography (CT) to cone-beam CT (CBCT) deformable image registration (DIR) is a crucial step in adaptive radiation therapy. Current intensity-based registration algorithms, such as demons, may fail in the context of CT-CBCT DIR because of inconsistent intensities between the two modalities. In this paper, we propose a variant of demons, called deformation with intensity simultaneously corrected (DISC), to deal with CT-CBCT DIR. DISC distinguishes itself from the original demons algorithm by performing an adaptive intensity correction step on the CBCT image at every iteration step of the demons registration. Specifically, the intensity correction of a voxel in CBCT is achieved by matching the first and the second moments of the voxel intensities inside a patch around the voxel with those on the CT image. It is expected that such a strategy can remove artifacts in the CBCT image, as well as ensuring the intensity consistency between the two modalities. DISC is implemented on computer graphics processing units in compute unified device architecture (CUDA) programming environment. The performance of DISC is evaluated on a simulated patient case and six clinical head-and-neck cancer patient data. It is found that DISC is robust against the CBCT artifacts and intensity inconsistency and significantly improves the registration accuracy when compared with the original demons.
Xin Zhen; Xuejun Gu; Hao Yan; Linghong Zhou; Xun Jia; Steve B Jiang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-03
Journal Detail:
Title:  Physics in medicine and biology     Volume:  57     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-17     Completed Date:  2013-03-18     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6807-26     Citation Subset:  IM    
Center for Advanced Radiotherapy Technologies, Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92037-0843, USA.
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MeSH Terms
Cone-Beam Computed Tomography / methods*
Head and Neck Neoplasms / radiography
Image Processing, Computer-Assisted / methods*
Time Factors
Grant Support
1R01CA154747-01/CA/NCI NIH HHS; R01 CA154747/CA/NCI NIH HHS

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