| CT-quantified emphysema distribution is associated with lung function decline. | |
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MedLine Citation:
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PMID: 22323577 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Emphysema distribution is associated with COPD. It is however unknown whether CT-quantified emphysema distribution (upper/lower lobe) is associated with lung function decline in heavy (former) smokers.587 male participants underwent lung CT-scanning and pulmonary function testing at baseline and after a median (interquartile range) follow-up of 2.9 (2.8-3.0) years. The lungs were automatically segmented based on anatomically defined lung lobes. Severity of emphysema was automatically quantified per anatomical lung lobe and was expressed as the 15(th) percentile (HU-point below which 15% of the low attenuation voxels are distributed (Perc15)). The CT-quantified emphysema distribution was based on principal component analysis. Linear mixed models were used to assess the association of emphysema distribution with FEV1/FVC, FEV1 and FVC-decline.Mean (SD) age was 60.2 (5.4) years, mean baseline FEV1/FVC was 71.6 (9.0) % and overall mean Perc15 was -908.5 (20.9) HU. Participants with upper lobe predominant CT-quantified emphysema had a lower FEV1/FVC, FEV1 and FVC after follow-up compared to participants with lower lobe predominant CT-quantified emphysema (p=0.001), independent of the total extent of CT-quantified emphysema.Heavy (former) smokers with upper lobe predominant CT-quantified emphysema have a more rapid decrease in lung function than those with lower lobe predominant CT-quantified emphysema. |
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Authors:
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F A A M Hoesein; E van Rixkoort; B van Ginneken; P A de Jong; M Prokop; J-W J Lammers; P Zanen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-9 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dept of Respiratory Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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