Document Detail

CT features of neutropenic enterocolitis in adult patients with hematological diseases undergoing chemotherapy.
MedLine Citation:
PMID:  21077023     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study investigates the features of neutropenic enterocolitis (NE) in adults.
MATERIALS AND METHODS: Chart and radiology report reviews were used to identify neutropenic patients with hematological diseases undergoing chemotherapy, who had CT scans for the clarification of abdominal symptoms between October 2003 and October 2009. Patients with any cause for enteritis other than NE were excluded. The scans were analyzed with respect to imaging features and location. Morphological findings were correlated with clinical data.
RESULTS: Thirty-one patients with NE (median age 46 years; range 20 - 75) could be identified. Wall thickening and hyperemia could be found in all bowel segments from jejunum to rectum. The right hemicolon was the most frequent location in 19 patients (61%). Involvement was generalized in 6 patients (19%) and segmental in 25 cases (81%). The longer the duration of neutropenia, the more likely generalized involvement of the bowel was. In 8 patients who underwent CT follow-up, the appearance of bowel segments had completely (n = 5) or partially (n = 3) returned to normal at the latest 14 days after the initial diagnosis. Eight patients (26%) died 1 - 78 days after NE, 7 of who had previously recovered from NE.
CONCLUSION: CT findings are useful for the diagnosis of NE and should be considered even in the presence of isolated small bowel involvement. The terms NE and typhlitis should thus no longer be used synonymously.
M N Vogel; B Goeppert; O Maksimovic; H Brodoefel; C Faul; C D Claussen; M Horger
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Publication Detail:
Type:  Journal Article     Date:  2010-11-12
Journal Detail:
Title:  RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin     Volume:  182     ISSN:  1438-9010     ISO Abbreviation:  Rofo     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507497     Medline TA:  Rofo     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1076-81     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Department of Diagnostic and Interventional Radiology, Eberhard-Karls-Universität, Tübingen.
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MeSH Terms
Antineoplastic Agents / therapeutic use,  toxicity*
Enterocolitis, Neutropenic / chemically induced*,  radiography*
Follow-Up Studies
Hematologic Diseases / drug therapy*
Image Processing, Computer-Assisted*
Intestinal Mucosa / radiography
Intestine, Large / radiography
Intestine, Small / radiography
Middle Aged
Remission, Spontaneous
Sensitivity and Specificity
Tomography, X-Ray Computed*
Young Adult
Reg. No./Substance:
0/Antineoplastic Agents

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