| CT diagnostic features of Alzheimer disease: importance of the choroidal/hippocampal fissure complex. | |
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MedLine Citation:
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PMID: 2105589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuropathologic changes in the temporal lobe, including focal atrophy of the subiculum and entorhinal cortex, have been described in association with Alzheimer disease. We studied the usefulness of detecting temporal-lobe structural changes on CT in making the diagnosis of Alzheimer disease. The dementia imaging protocol we use includes thin-section (5 mm) cuts of the temporal lobe oriented 20 degrees negative (caudal) to the plane of the canthomeatal line. Thirty-four patients with suspected Alzheimer disease and 20 normal elderly control subjects, all between 65 and 80 years old, were studied with a standard protocol that also included neurologic and medical examinations and detailed psychometric testing. All the temporal-lobe evaluations of the five variables measured were significantly associated with the presence or absence of Alzheimer disease. Almost all Alzheimer patients showed evidence of mild or greater severity of overall temporal-lobe atrophy. The absence of temporal-lobe atrophy, seen in approximately one half the normal cases, identified normal individuals with a high degree of specificity (95%). The presence of characteristic hippocampal lucency, apparently due to enlargement of the choroid and hippocampal fissures, showed the highest sensitivity and classification accuracy of all the variables tested (82 and 80% respectively; p less than .001), correctly identifying 82% of Alzheimer patients and 80% of Alzheimer patients and control subjects. These results indicate that CT detection of structural changes in the temporal lobe and hippocampus strongly support the diagnosis of Alzheimer disease. A temporal-lobe imaging protocol for CT, and by extension for MR, is suggested for the evaluation of patients with the clinical diagnosis of a dementing disorder. |
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Authors:
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A E George; M J de Leon; L A Stylopoulos; J Miller; A Kluger; G Smith; D C Miller |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 11 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 1990 Jan-Feb |
Date Detail:
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Created Date: 1990-03-15 Completed Date: 1990-03-15 Revised Date: 2008-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 101-7 Citation Subset: IM |
Affiliation:
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Department of Radiology (Neuroradiology), New York University School of Medicine, NY 10016. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / pathology, radiography* Choroid Plexus / pathology* Female Hippocampus / pathology* Humans Male Middle Aged Temporal Lobe / pathology* Tomography, X-Ray Computed* |
| Grant Support | |
ID/Acronym/Agency:
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MH36969/MH/NIMH NIH HHS |
| Comments/Corrections | |
Comment In:
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AJNR Am J Neuroradiol. 1991 May-Jun;12(3):583-4
[PMID:
2058524
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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