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CT coronary plaque burden in asymptomatic patients with familial hypercholesterolaemia.
MedLine Citation:
PMID:  21565855     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective To determine the calcium score and coronary plaque burden in asymptomatic statin-treated patients with heterozygous familial hypercholesterolaemia (FH) compared with a control group of patients with low probability of coronary artery disease, having non-anginal chest pain, using CT. Design, setting and patients 101 asymptomatic patients with FH (mean age 53±7&emsp14;years; 62 men) and 126 patients with non-anginal chest pain (mean age 56±7&emsp14;years; 80 men) underwent CT calcium scoring and CT coronary angiography. All patients with FH were treated with statins during a period of 10±8&emsp14;years before CT. The coronary calcium score and plaque burden were determined and compared between the two patient groups. Results The median total calcium score was significantly higher in patients with FH (Agatston score=87, IQR 5-367) than in patients with non-anginal chest pain (Agatston score=7, IQR 0-125; p<0.001). The overall coronary plaque burden was significantly higher in patients with FH (p<0.01). Male patients with FH, whose low-density lipoprotein cholesterol levels were reduced by statins below 3.0&emsp14;mmol/l, had significantly less coronary calcium (p<0.01) and plaque burden (p=0.02). Conclusion The coronary plaque burden is high in asymptomatic middle-aged patients with FH despite intense statin treatment.
Authors:
Lisan A Neefjes; Gert-Jan R Ten Kate; Alexia Rossi; Annette J Galema-Boers; Janneke G Langendonk; Annick C Weustink; Adriaan Moelker; Koen Nieman; Nico R Mollet; Gabriel P Krestin; Eric J Sijbrands; Pim J de Feyter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-12
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  -     ISSN:  1468-201X     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Erasmus Medical Center, Rotterdam, The Netherlands.
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