Document Detail

CT coronary angiography: coronary CT-flow quantification supplements morphological stenosis analysis.
MedLine Citation:
PMID:  23265182     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Our rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic (CT) changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying the significance and hemodynamic relevance of a stenosis and thereby supplement as a functional parameter for morphological stenosis analysis.
METHODS: A total of 50 patients prospectively underwent computed tomography coronary angiography (coronary CTA) in a multidetector CT scanner (Brilliance 64, Philips)±1 day before or after invasive coronary angiography (ICA). Immediately thereafter, 2 radiologists reviewed the imaging data to detect any vessel segments with morphology poorly evaluable by coronary CTA. A locally constant cyclical measurement was acquired in these coronary arteries in breath-hold technique during the passage of a 50ml bolus of contrast media. For analysis, time-density curves of the bolus passage were registered in the coronary artery and the aorta (internal reference), the up-slopes were determined and correlated with each other. The results were compared with the ICA findings.
RESULTS: 47 of 50 CT flow measurements were evaluable. A good correlation was found between the degrees of stenosis and slope ratios in aorta and coronary artery (R(2)=0.92). The threshold corridor was 0.55-0.77 for distinguishing hemodynamically (≥70%) from non-hemodynamically relevant stenoses.
CONCLUSIONS: CT-based coronary artery flow measurements (CTFM) correlate well with the angiographically determined degree of stenosis and can elevate by non-invasive means the diagnostic accuracy of coronary CTA. From both a clinically diagnostic and scientific standpoint, CTFM proves a suitable method for quantifying coronary blood flow.
H Bovenschulte; B Krug; T Schneider; H Schwabe; C Kabbasch; C Bangard; M Hellmich; G Michels; D Maintz; K Lackner
Publication Detail:
Type:  Journal Article     Date:  2012-12-21
Journal Detail:
Title:  European journal of radiology     Volume:  82     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-08-23     Revised Date:  2014-01-15    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  608-16     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Blood Flow Velocity
Contrast Media / diagnostic use
Coronary Angiography / methods*
Coronary Stenosis / radiography*
Iopamidol / analogs & derivatives,  diagnostic use
Middle Aged
Prospective Studies
Tomography, X-Ray Computed / methods*
Reg. No./Substance:
0/Contrast Media; 17E17JBP8L/iomeprol; JR13W81H44/Iopamidol
Comment In:
Rofo. 2013 Dec;185(12):1128

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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