Document Detail

CT characterization of inflammatory paranasal sinus disease in cystic fibrosis.
MedLine Citation:
PMID:  11972457     Owner:  NLM     Status:  MEDLINE    
PURPOSE: In patients with cystic fibrosis (CF) the prevalence of paranasal sinus affection approaches 100%. We hypothesized that the hyperviscous mucus reducing mucociliary clearance in CF patients could give sinonasal inflammatory patterns different from those in non-CF patients. We wanted to compare the extent and distribution of paranasal sinus disease and the inflammatory patterns in these two groups of patients. MATERIAL AND METHODS: One-hundred-and-eight CF patients (3-54 years old) and 79 controls (7-51 years old) with paranasal sinus disease confirmed at coronal CT were compared. The extent of disease was noted for each sinus and summed for all sinuses. Inflammatory patterns were identified and classified into: 1) routine surgery group (sporadic, infundibular and ostiomeatal complex (OMC) patterns) and 2) complex surgery group (sinonasal polyposis and sphenoethmoid recess (SER) patterns). RESULTS: CF patients had more widespread sinonasal inflammatory changes and more advanced disease for each sinus. Most CF patients displayed sinonasal polyposis and SER patterns while most controls displayed sporadic, infundibular or OMC patterns. As a result, 67% of CF patients were classified to the complex surgery group, compared to only 19% of controls. CONCLUSION: The impaired mucociliary clearance in CF causes widespread inflammatory paranasal sinus disease, with inflammatory patterns more often requiring extensive surgery, with a higher risk of cerebrospinal fluid leak or bleeding, or involving areas that are more difficult to reach with the endoscope.
Heidi B Eggesbø; S Søvik; S Dølvik; F Kolmannskog
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  43     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-04-25     Completed Date:  2002-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  21-8     Citation Subset:  IM    
Department of Radiology, Aker University Hospital, University of Oslo, NO-0514 Oslo, Norway.
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MeSH Terms
Child, Preschool
Cystic Fibrosis / complications*,  physiopathology,  radiography*
Mucus / physiology,  radiography
Paranasal Sinus Diseases / etiology*,  physiopathology,  radiography*
Prospective Studies
Sinusitis / etiology*,  physiopathology,  radiography*
Tomography, X-Ray Computed*

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