Document Detail

CT angiography in acute stroke: does it provide additional information on occurrence of infarction and functional outcome after 3 months?
MedLine Citation:
PMID:  16888376     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether acute phase intracranial CT angiography (CTA) independently predicts infarction and functional outcome in ischemic stroke. METHODS: Hundred and fifty-one consecutive patients with acute (<12 h) ischemic stroke who received intracranial CTA were investigated. Stroke severity on admission was determined using the National Institute of Health Stroke Scale (NIHSS). Reconstructed CTAs were investigated for relevant pathology. Follow-up imaging was performed 24-48 h after admission. Functional outcome was assessed after 3 months using the modified Rankin scale. Single factor and multiple logistic regression analyses were performed to predict infarction and dependency (modified Rankin scale > or = 3) on follow-up. RESULTS: Median NIHSS on admission was 10 (IQR 3-14). Out of the 151 patients, 61 (40%) had pathological CTA findings. Infarction was demonstrated in 60/61 patients (98%) with and in 67/90 patients (74%) without vessel pathology. Presence of infarction on follow-up imaging and dependency at 3 months were correlated with pathological CTA findings on admission in single factor analysis (each p < 0.001). After adjustment for age (> or =/<65 years), NIHSS (> or =/<10), sex, therapy, and time to presentation (> or =/<3 h), only NIHSS > or = 10 on admission was predictive of dependency at follow-up (p < 0.001). CONCLUSIONS: Pathological CTA findings in the acute phase of ischemic stroke do not independently predict a poor outcome at 3 months after acute stroke.
Martin A Ritter; Tobias Poeplau; Anne Schaefer; Stephan P Kloska; Rainer Dziewas; E Bernd Ringelstein; Walter Heindel; Darius G Nabavi
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Publication Detail:
Type:  Journal Article     Date:  2006-08-03
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  22     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-01-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  362-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 S. Karger AG, Basel.
Department of Neurology, University of Münster, Münster, Germany.
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MeSH Terms
Acute Disease
Brain Infarction / etiology,  physiopathology*,  radiography*
Cerebral Angiography*
Factor Analysis, Statistical
Follow-Up Studies
Logistic Models
Predictive Value of Tests
Prospective Studies
Severity of Illness Index
Stroke / complications,  physiopathology*,  radiography*,  therapy
Thrombolytic Therapy
Time Factors
Tomography, X-Ray Computed*
Treatment Outcome

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